52011-52-6 Usage
Uses
Used in Pharmaceutical Industry:
2,5-Anhydro-D-mannitol-1-phosphate, Barium Salt Hydrate is used as an inhibitor for gluconeogenesis in isolated hepatocytes. It helps prevent hormonal stimulation of gluconeogenesis and the corresponding decrease in lactate production from dihydroxyacetone, which can be beneficial in managing and treating certain metabolic disorders and conditions related to glucose regulation.
Used in Research and Development:
In the field of research and development, 2,5-Anhydro-D-mannitol-1-phosphate, Barium Salt Hydrate is utilized as a tool to study the mechanisms and regulation of gluconeogenesis. This can lead to a better understanding of glucose metabolism and the development of new therapeutic strategies for diabetes and other related conditions.
Used in Biochemical Analysis:
2,5-Anhydro-D-mannitol-1-phosphate, Barium Salt Hydrate can be employed in biochemical analysis to investigate the role of gluconeogenesis in various biological processes. This may include studying the effects of different hormones, enzymes, and other factors on glucose production and regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 52011-52-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,1 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52011-52:
(7*5)+(6*2)+(5*0)+(4*1)+(3*1)+(2*5)+(1*2)=66
66 % 10 = 6
So 52011-52-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H13O8P/c7-1-3-5(8)6(9)4(14-3)2-13-15(10,11)12/h3-9H,1-2H2,(H2,10,11,12)/t3-,4-,5-,6-/m1/s1
52011-52-6Relevant academic research and scientific papers
Synthesis of Selectively Labeled D-Fructose and D-Fructose Phosphate Analogues Locked in the Cyclic Furanose Form
Persky, Rachel,Albeck, Amnon
, p. 5632 - 5638 (2007/10/03)
2,5-Anhydroglucitol and 2,5-anhydromannitol and their 6-phosphate and 1,6-diphosphate derivatives are cyclic analogues of the α and β anomers of D-fructofuranose, D-fructofuranose-6-phosphate, and D-fructofuranose-1,6-diphosphate. They were synthesized from protected D-mannose or D-glucose. The synthetic method was developed with emphasis on selective 2H labeling of these compounds, as a model for 3H incorporation, which will be used for further biochemical studies. A key cyclization step, based on a benzyl ether nucleophilic attack on an activated alcohol, constructed the ring system. The stereochemistry at C2 (α/β anomers) and at C5 (D sugar) was controlled by selective epimerizations. Mono- and diphosphate analogues were obtained from the same intermediate by changing the sequence of deprotection and phosphorylation steps.
