5202-11-9Relevant academic research and scientific papers
Synthesis of benzyl sulfidesviasubstitution reaction at the sulfur of phosphinic acid thioesters
Nishiyama, Yoshitake,Hosoya, Takamitsu,Yoshida, Suguru
supporting information, p. 5771 - 5774 (2020/06/03)
An ambident electrophilicity of phosphinic acid thioesters is disclosed. Unexpected carbon-sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. The developed method for benzyl sulfides has a wide substrate scope and was applicable for the synthesis of a drug analog.
Friedel–Crafts reactions of acyl trifluoromethanesulfonates and cyclic acylsulfonium cations generated from acyl fluorides
Raghavendra Rao,Vallée, Yannick
, p. 4442 - 4447 (2016/07/06)
Reactive acyl trifluoromethanesulfonates are formed from the reaction of acyl fluorides with trimethylsilyl trifluoromethanesulfonate (TMSOTf). These electrophiles undergo Friedel–Crafts reactions with electron-rich aromatics at room temperature. When a sulfur atom is present at their γ position, their cyclization to acylsulfonium cations is observed and is followed by a rearrangement leading to benzothiepinones (or dibenzo[b,e]thiepinones) in 40–85% yield.
Acid-Catalyzed Reactions of Ortho-Substituted Benzohydroxamic Acids in Polyphosphoric Acid (PPA)
Chhaya, P. N.,Nimbalkar, M. M.,Hosangadi, B. D.
, p. 4458 - 4460 (2007/10/02)
Ortho-substituted benzohydroxamic acids undergo a variety of reactions when treated with PPA.The nature of substituents on the ring and on the functional group CONHOH plays a key role in influencing the reaction pathways.The difference in behavior may arise due to change in site of protonation depending upon the substitution.However, no clear-cut relationship could be established as attempts to monitor reactions on NMR proved inconclusive.
