52042-27-0

Usage

InChI:InChI=1/C11H12ClNO4/c12-7-1-2-10-9(3-7)13(4-8(15)5-14)11(16)6-17-10/h1-3,8,14-15H,4-6H2

Upstream product

• 7652-29-1 6-chloro-2H-1,4-benzoxazin-3(4H)-one 
• 96-24-2 3-monochloro-1,2-propanediol 
• 35588-38-6 2-chloro-N-(5-chloro-2-hydroxyphenyl)acetamide 

Relevant academic research and scientific papers

Derivatives of 3-oxo-2,3-dihydro-1,4-benzoxazine

The invention relates to new derivatives of 3-oxo-2,3-dihydro-1,4-benzoxazine corresponding to the general formula SPC1 In which R1 is selected from the group consisting of the hydrogen atom and a lower alkyl group; R2, r3 and R4 which are identical or different, are selected from the group consisting of the hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, a lower alkoxy group and R4 may be an allyl group; R5 is selected from the group consisting of the hydrogen atom and an acyl group, preferably acetyl. These derivatives can be used for therapeutic purposes, more especially as analgesics and anti-oedematous agents.

Synthesis and pharmacological activity of 4 substituted 2,3 dihydro 1,4 benzoxazin 3 ones

Some derivatives of 3 oxo 2,3 dihydro 1,4 benzoxazine substituted with aminoalkyl and hydroxyalkyl groups were prepared and their analgesic activity studied. This was weak for the amino, but very important for the propranediol derivatives. One of them, AN