52055-86-4

Upstream product

• 873378-14-4 4-methoxy-benzofuran-5-carbonyl chloride 
• 18815-73-1 methylzinc iodide 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 69722-46-9 1-(4-hydroxy-benzofuran-5-yl)-ethanone 
• 74-88-4 methyl iodide 
• 492440-03-6 1-[4-(2,2-diethoxyethoxy)-2-hydroxyphenyl]ethan-1-one 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 484-33-3 pongamol 

Downstream Products

• 101450-96-8 1-(4-methoxy-benzofuran-5-yl)-ethanone-(2,4-dinitro-phenylhydrazone) 
• 69722-46-9 1-(4-hydroxy-benzofuran-5-yl)-ethanone 
• 121324-08-1 (2Z)-3-hydroxy-1-(4–methoxy-1-benzofuran-5-yl)-3-phenylprop 2-en-1-one 
• 83728-90-9 2'-Methoxy-4-methylfurano<3'',2'':3',4'>chalcone 
• 484-33-3 pongamol 
• 130824-74-7 (E)-9-O-Methylpongamol 
• 64280-20-2 ovalitenin A 

Relevant academic research and scientific papers

Preparation method and application of pongamol

The invention belongs to the field of medicinal chemistry, and relates to a preparation method and application of pongamol. The preparation method comprises the following steps: with 1,3-cyclohexanedione (6) as a starting raw material, carrying out a cyclization reaction to obtain 6,7-dihydro-4-(5H)-benzofuranone (7); carrying out acylation reaction on the compound (7) to obtain 5-acetyl-6,7-dihydro-4-(5H)-benzofuranone (8); carrying out dehydrogenation reaction on the compound (8) to obtain 1-(4-hydroxy-5-benzofuryl) ethyl ketone (3); carrying out methylation reaction on the compound (3) to obtain 1-(4-methoxy-5-benzofuryl) ethyl ketone (4); and condensing the compound (4) with benzoyl chloride to obtain the pongamol. According to the preparation method, the selected reagents are cheap and easy to obtain, the post-treatment method is simple, the reaction conditions are mild, and the product yield is high. Pharmacological activity experiments show that the synthesized compound has nerve injury resistance and anti-inflammatory activity, which means that the compound has a good application prospect in the field of treatment of nerve injury and inflammation related diseases.

Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors

Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in m

Amberlyst 15-catalyzed efficient synthesis of 5-acetyl-4-hydroxy-coumarone and 5-acetyl-6-hydroxy-coumarone: Crucial precursors for several naturally occurring furanoflavones

A novel approach to the total synthesis of naturally occurring furanoflavones and furanochalcones is described. Angular and linear furanoflavones and furanochalcones have been prepared in just four steps, using economical reagents and simple reaction cond

A NEW ROUTE FOR THE SYNTHESIS OF FURANOFLAVONE AND FURANOCHALCONE NATURAL PRODUCTS

An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.Key Words: Total synthesis, lanceolatin B, pongaglabrone, isopongaglabol, isopongaglabol methyl ether, pongol, pongamol, ovalite