69722-46-9

Upstream product

• 482-00-8 lanceolatin B 
• 164531-76-4 5-acetyl-4-oxo-4,5,6,7-tetrahydrobenzofuran 
• 38987-00-7 2,4-dihydroxy-3-allylacetophenone 
• 492440-03-6 1-[4-(2,2-diethoxyethoxy)-2-hydroxyphenyl]ethan-1-one 
• 1310106-08-1 1-(4-(2,2-dimethoxyethoxy)-2-hydroxyphenyl)ethanone 
• 3424-77-9 3-formyl-2,4-dihydroxyacetophenone 
• 873378-14-4 4-methoxy-benzofuran-5-carbonyl chloride 
• 40815-74-5 4-allyloxy-2-hydroxyacetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 484-33-3 pongamol 
• 52055-86-4 2-methoxy-furano<3',2':3,4>acetophenone 

Downstream Products

• 77373-19-4 (E)-1-(4-hydroxybenzofuran-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 52055-86-4 2-methoxy-furano<3',2':3,4>acetophenone 
• 112606-78-7 (E)-1-(4-hydroxybenzofuran-5-yl)-3-phenylprop-2-en-1-one 
• 756891-29-9 2'-hydroxy-4-prenyloxy-furano(2'',3'':4',3')chalcone 
• 862823-97-0 4-trifluoromethyl-benzoic acid 5-acetyl-benzofuran-4-yl ester 
• 1310106-73-0 ethyl 2-oxo-4-(4-oxo-4H-furo[2,3-h]chromen-3-yl)-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1310106-74-1 2-methoxyethyl 6-methyl-2-oxo-4-(4-oxo-4H-furo[2,3-h]chromen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1279111-33-9 (E)-3-(4-(benzyloxy)phenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-36-2 (E)-1-(4-hydroxybenzofuran-5-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 1279111-47-5 2-(3,4-bis(benzyloxy)phenyl)-3-hydroxy-4H-furo[2,3-h]chromen-4-one 
• 1279111-34-0 (E)-3-(4-(benzyloxy)-3-methoxyphenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-37-3 (E)-3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-32-8 (E)-1-(4-hydroxybenzofuran-5-yl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one 
• 1279111-38-4 (E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 

Relevant academic research and scientific papers

Preparation method and application of pongamol

The invention belongs to the field of medicinal chemistry, and relates to a preparation method and application of pongamol. The preparation method comprises the following steps: with 1,3-cyclohexanedione (6) as a starting raw material, carrying out a cyclization reaction to obtain 6,7-dihydro-4-(5H)-benzofuranone (7); carrying out acylation reaction on the compound (7) to obtain 5-acetyl-6,7-dihydro-4-(5H)-benzofuranone (8); carrying out dehydrogenation reaction on the compound (8) to obtain 1-(4-hydroxy-5-benzofuryl) ethyl ketone (3); carrying out methylation reaction on the compound (3) to obtain 1-(4-methoxy-5-benzofuryl) ethyl ketone (4); and condensing the compound (4) with benzoyl chloride to obtain the pongamol. According to the preparation method, the selected reagents are cheap and easy to obtain, the post-treatment method is simple, the reaction conditions are mild, and the product yield is high. Pharmacological activity experiments show that the synthesized compound has nerve injury resistance and anti-inflammatory activity, which means that the compound has a good application prospect in the field of treatment of nerve injury and inflammation related diseases.

Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents

Series of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 7a-7zb, 8a-8d and 9a-9d were synthesized and screened for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) and cytotoxicity against three human cancer cell lines including A549, SK-N-SH and HeLa. The results indicate that six compounds are more potent and 7za is most effective anti-mycobacterial derivative compared to the standard drugs Ethambutol and Ciprofloxacin. However, 12 compounds exhibited cytotoxicity against human neuroblastoma cell line; amongst them the compound 7v is most effective compared to the standard drug Doxorubicin. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5- carboxylates.

New furanoflavanoids, intestinal α-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.)

A bioassay-guided fractionation and chemical examination of antihyperglycemic root extract of Derris indica resulted in isolation and characterization of two new furanoflavanoids (1, 2) along with thirteen known compounds (3-15). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested in vitro for intestinal α-glucosidase inhibitory and DPPH radical activity. New compounds (1, 2) displayed moderate intestinal α-glucosidase inhibitory as well as free radical scavenging activity. Other compounds also displayed varying degrees of moderate intestinal α-glucosidase inhibitory activity. Pongamol (6) displayed potent intestinal α-glucosidase inhibition.

Synthesis of benzofuran scaffold-based potential PTP-1B inhibitors

Protein tyrosine phosphatase 1B (PTP-1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP-1B knockout mice showed increased insulin sensitivity in m

A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers

Benzofurans functionalized with hydroxy and acetyl functionalities are not only the core structures found in a large number of biologically important natural products, but also the vital precursors for several naturally occurring furanoflavonoids. Numerou

Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Studies have shown that PTP1B knock-out mice showed increased insulin sensitivity in mu

Amberlyst 15-catalyzed efficient synthesis of 5-acetyl-4-hydroxy-coumarone and 5-acetyl-6-hydroxy-coumarone: Crucial precursors for several naturally occurring furanoflavones

A novel approach to the total synthesis of naturally occurring furanoflavones and furanochalcones is described. Angular and linear furanoflavones and furanochalcones have been prepared in just four steps, using economical reagents and simple reaction cond

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).

A NEW ROUTE FOR THE SYNTHESIS OF FURANOFLAVONE AND FURANOCHALCONE NATURAL PRODUCTS

An efficient synthesis of furanoflavones and furanochalcones has been carried out starting from a dihydrobenzofuran derivative.Key Words: Total synthesis, lanceolatin B, pongaglabrone, isopongaglabol, isopongaglabol methyl ether, pongol, pongamol, ovalite