69722-46-9

Basic information

• Product Name: 1-(4-HYDROXYBENZOFURAN-5-YL)ETHANONE
• Synonyms: 1-(4-HYDROXYBENZOFURAN-5-YL)ETHANONE
• CAS NO: 69722-46-9
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 0
• Mol File: 69722-46-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-HYDROXYBENZOFURAN-5-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HYDROXYBENZOFURAN-5-YL)ETHANONE(69722-46-9)
• EPA Substance Registry System: 1-(4-HYDROXYBENZOFURAN-5-YL)ETHANONE(69722-46-9)

Safety Data

• Hazardous Substances Data: 69722-46-9(Hazardous Substances Data)

Upstream product

• 52055-86-4 2-methoxy-furano<3',2':3,4>acetophenone 
• 484-33-3 pongamol 
• 482-00-8 lanceolatin B 
• 164531-76-4 5-acetyl-4-oxo-4,5,6,7-tetrahydrobenzofuran 
• 38987-00-7 2,4-dihydroxy-3-allylacetophenone 
• 492440-03-6 1-[4-(2,2-diethoxyethoxy)-2-hydroxyphenyl]ethan-1-one 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 40815-74-5 4-allyloxy-2-hydroxyacetophenone 
• 873378-14-4 4-methoxy-benzofuran-5-carbonyl chloride 
• 3424-77-9 3-formyl-2,4-dihydroxyacetophenone 
• 1310106-08-1 1-(4-(2,2-dimethoxyethoxy)-2-hydroxyphenyl)ethanone 

Downstream Products

• 108978-29-6 1-(4-benzoyloxy-benzofuran-5-yl)-ethanone 
• 77373-19-4 (E)-1-(4-hydroxybenzofuran-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 52055-86-4 2-methoxy-furano<3',2':3,4>acetophenone 
• 756891-29-9 2'-hydroxy-4-prenyloxy-furano(2'',3'':4',3')chalcone 
• 1310106-73-0 ethyl 2-oxo-4-(4-oxo-4H-furo[2,3-h]chromen-3-yl)-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1310106-74-1 2-methoxyethyl 6-methyl-2-oxo-4-(4-oxo-4H-furo[2,3-h]chromen-3-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1279111-35-1 (E)-3-(3,4-bis(benzyloxy)phenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-38-4 (E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-33-9 (E)-3-(4-(benzyloxy)phenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-36-2 (E)-1-(4-hydroxybenzofuran-5-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 1279111-47-5 2-(3,4-bis(benzyloxy)phenyl)-3-hydroxy-4H-furo[2,3-h]chromen-4-one 
• 1279111-34-0 (E)-3-(4-(benzyloxy)-3-methoxyphenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-37-3 (E)-3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxybenzofuran-5-yl)prop-2-en-1-one 
• 1279111-32-8 (E)-1-(4-hydroxybenzofuran-5-yl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Preparation method and application of pongamol

The invention belongs to the field of medicinal chemistry, and relates to a preparation method and application of pongamol. The preparation method comprises the following steps: with 1,3-cyclohexanedione (6) as a starting raw material, carrying out a cyclization reaction to obtain 6,7-dihydro-4-(5H)-benzofuranone (7); carrying out acylation reaction on the compound (7) to obtain 5-acetyl-6,7-dihydro-4-(5H)-benzofuranone (8); carrying out dehydrogenation reaction on the compound (8) to obtain 1-(4-hydroxy-5-benzofuryl) ethyl ketone (3); carrying out methylation reaction on the compound (3) to obtain 1-(4-methoxy-5-benzofuryl) ethyl ketone (4); and condensing the compound (4) with benzoyl chloride to obtain the pongamol. According to the preparation method, the selected reagents are cheap and easy to obtain, the post-treatment method is simple, the reaction conditions are mild, and the product yield is high. Pharmacological activity experiments show that the synthesized compound has nerve injury resistance and anti-inflammatory activity, which means that the compound has a good application prospect in the field of treatment of nerve injury and inflammation related diseases.

New furanoflavanoids, intestinal α-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.)

A bioassay-guided fractionation and chemical examination of antihyperglycemic root extract of Derris indica resulted in isolation and characterization of two new furanoflavanoids (1, 2) along with thirteen known compounds (3-15). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested in vitro for intestinal α-glucosidase inhibitory and DPPH radical activity. New compounds (1, 2) displayed moderate intestinal α-glucosidase inhibitory as well as free radical scavenging activity. Other compounds also displayed varying degrees of moderate intestinal α-glucosidase inhibitory activity. Pongamol (6) displayed potent intestinal α-glucosidase inhibition.

A controlled synthesis of nature-mimicking benzofurans and their corresponding dimers

Benzofurans functionalized with hydroxy and acetyl functionalities are not only the core structures found in a large number of biologically important natural products, but also the vital precursors for several naturally occurring furanoflavonoids. Numerou