52074-75-6Relevant academic research and scientific papers
Ammonium chloride catalyzed Knoevenagel condensation in PEG-400 as ecofriendly solvent
Waghmare, Smita R.
, p. 849 - 855 (2021/09/28)
A simple and selective green methodology has been successfully developed for Knoevenagel condensation in polyethylene glycol-400 using 10 mol % ammonium chloride as catalyst. The method is applicable to a wide range of aromatic, heteroaromatic and α,β-unsaturated aldehydes. The reactions have been found to be clean and free from the formation of the Michael adduct.
Direct amino acid-catalyzed cascade reductive alkylation of arylacetonitriles: High-yielding synthesis of ibuprofen analogs
Ramachary, Dhevalapally B.,Shiva Prasad
supporting information; experimental part, p. 5246 - 5251 (2010/11/03)
A novel approach for a one-pot, three-component reductive alkylation (TCRA) reaction of arylacetonitriles-containing electron-withdrawing groups with aldehydes/ketones and 1,4-dihydropyridine via iminium-catalysis has been developed. Many TCRA reaction products have direct applications in agricultural and pharmaceutical chemistry.
