52083-08-6

Basic information

• Product Name: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride
• Synonyms: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride;4-hydroxy-naphthalene-1,8-dicarboxylic anhydride;6-hydroxybenzo[de]isochromene-1,3-dione;4-hydroxy-1,8-naphthalic anhydride
• CAS NO: 52083-08-6
• Molecular Formula: C₁₂H₆O₄
• Molecular Weight: 214.17364
• Mol File: 52083-08-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 350-351 °C
• Boiling Point: 507.6±33.0 °C(Predicted)
• Appearance: /
• Density: 1.585±0.06 g/cm3(Predicted)
• PKA: 7.27±0.20(Predicted)
• CAS DataBase Reference: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride(52083-08-6)
• EPA Substance Registry System: 4-Hydroxy-1,8-naphthalenedicarboxylic anhydride(52083-08-6)

Safety Data

• Hazardous Substances Data: 52083-08-6(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-1,8-naphthalenedicarboxylic anhydride is a chemical compound with the molecular formula C12H6O6. It is also known as 1,8-naphthalic anhydride and is commonly used as a precursor in the synthesis of various organic compounds. This chemical is a white solid at room temperature and is insoluble in water. It is primarily used in the production of dyes, pigments, and pharmaceutical intermediates. Additionally, it is a versatile building block in the chemical industry, serving as a key starting material for the synthesis of a wide range of organic compounds.

Upstream product

• 6492-86-0 4-amino-1,8-naphthalic anhydride 
• 81-86-7 4-bromo-1,8-naphthalenedicarboxylic anhydride 
• 26848-63-5 4-sulfo-naphthalene-1,8-dicarboxylic acid 

Downstream Products

• 18644-22-9 4-amino-naphthalene-1,8-dicarboxylic acid 
• 90-15-3 α-naphthol 
• 2437-16-3 5-hydroxy-1-naphthoic acid 
• 4053-08-1 p-chloro-1,8-naphthalicanhydride 

Relevant articles and documents

Endoplasmic reticulum-targetable fluorescent probe for visualizing HClO in EC1 cells

The endoplasmic reticulum is the largest organelle in the cell. Studies have shown that the concentration of HClO is related to many diseases. A new type of probe R1 has positioned to the endoplasmic reticulum. The probe shows good positioning effect, excellent selectivity and high sensitivity, excellent anti-interference, and can quickly reach the response platform. The obvious color change can be used for naked eye observation. Due to its low cytotoxicity, probe R1 was successfully used for EC1 cells imaging under a laser scanning confocal microscope.

A Naphthalimide-Based Cd2+Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions

We have developed a novel naphthalimide-based Cd2+fluorescent probe (1), featuring almost no background response, high sensitivity and selectivity toward Cd2+through its high association constant [K=(2.10±0.423)×106], and a practical working pH range. Membrane-permeability was conferred on 1 by replacing the imide and amide substituents with n-butyl groups, and hence the derivative (4) has found practical utility on fluorescent imaging of Cd2+in HeLa cells. Comparison of fluorescent properties between various compounds derived from 1 has demonstrated that the carbamoylmethyl groups in 1 function not only as Cd2+chelators but also as promoters for photoinduced electron transfer (PET) by lowering the basicity of the two tertiary amino groups. As a result, 1 and 4 exhibited highly practical performance as Cd2+probes under neutral conditions.