2437-16-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Hydroxy-1-naphthoic acid is used as a precursor for the synthesis of various pharmaceuticals and organic compounds, due to its versatile reactivity and functional groups.
Used in Medicine:
5-Hydroxy-1-naphthoic acid is used as a potential anti-cancer and anti-inflammatory agent, as it has been studied for its biological activities.
Used in Research:
5-Hydroxy-1-naphthoic acid is used in research for its role in the biosynthesis of certain natural products and for studying its potential biological activities.
Used in Industry:
5-Hydroxy-1-naphthoic acid is used as a valuable chemical in various industrial applications, including the synthesis of pharmaceuticals and organic compounds.

InChI:InChI=1/C11H8O3/c12-10-6-2-3-7-8(10)4-1-5-9(7)11(13)14/h1-6,12H,(H,13,14)

Upstream product

• 72016-73-0 5-Aminonaphthalene-1-carbonitrile 
• 500546-50-9 5-cyano-naphthalene-1-sulfonic acid 
• 51307-69-8 5-sulfo-1-naphthoic acid 
• 52083-08-6 4-hydroxy-1,8-naphthalic anhydride 
• 86-55-5 1-naphthalenecarboxylic acid 
• 64-18-6 formic acid 
• 91-20-3 naphthalene 
• 83-55-6 5-amino-1-naphthol 
• 51934-37-3 5-methoxy-1-naphthoic acid 
• 32018-88-5 5-amino-1-naphthoic acid 
• 61735-51-1 1-iodo-5-methoxynaphthalene 
• 61735-56-6 5-iodonaphthalen-1-ol 

Downstream Products

• 91307-40-3 methyl 5-hydroxy-1-naphthoate 
• 51934-37-3 5-methoxy-1-naphthoic acid 
• 90-15-3 α-naphthol 
• 124-38-9 carbon dioxide 

Relevant academic research and scientific papers

BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu- opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors

A series of novel 8-substituted dipyridodiazepinone-based inhibitors were investigated for their antiviral activity against wild type human immunodeficiency virus (HIV-1) and the clinically prevalent K103N/Y181C mutant virus. Our efforts have resulted in a series of benzoic acid analogues that are potent inhibitors of HIV-1 replication against a panel of HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Furthermore, the combination of good antiviral potency, a broad spectrum of activity, and an excellent pharmacokinetic profile provides strong justification for the further development of compound 7 as a potential treatment for wild type and NNRT1-resistant HIV-1 infection.

Palladium(II)-catalyzed sequential hydroxylation-carboxylation of biphenyl using formic acid as a carbonyl source

(Equation Presented) A simultaneous hydroxylation-carboxylation of biphenyl occurred to give 4′-hydroxy-4-biphenylcarboxylic acid, which has wide potential application as a polyester monomer.

Hydroxylation of ionized aromatics including carboxylic acid or amine using recombinant Streptomyces lividans cells expressing modified biphenyl dioxygenase genes

The bphA1(2072)A2A3A4 gene cluster codes for a shuffled biphenyl dioxygenase holoenzyme with broad substrate specificity. These bphA1(2072)A2A3A4 genes were expressed in the actinomycetes Streptomyces lividans using a thiostrepton-inducible promoter PtipA. Biotransformation experiments of various aromatics including carboxylic acid or amine in their molecular structure, such as 1-naphthoic acid, 2-(1-naphthyl)acetic acid, diphenylamine, and 1-benzyl-4-piperidone, were performed using the recombinant S.lividans cells. These ionized aromatics were converted to the corresponding 1,2-dihydrodiol, mono- or tri-hydroxy forms in 48h. The structure of the converted products was determined by their EI-MS, 1H- and 13C NMR analysis, and several products were found to be novel compounds.