52085-96-8

Basic information

• Product Name: Benzenepropanoyl chloride, 4-chloro-
• Synonyms: Benzenepropanoyl chloride, 4-chloro-;3-(4-Chloro-phenyl)-propionyl chloride
• CAS NO: 52085-96-8
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.06522
• Mol File: 52085-96-8.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenepropanoyl chloride, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoyl chloride, 4-chloro-(52085-96-8)
• EPA Substance Registry System: Benzenepropanoyl chloride, 4-chloro-(52085-96-8)

Safety Data

• Hazardous Substances Data: 52085-96-8(Hazardous Substances Data)

Upstream product

• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
• 79-37-8 oxalyl dichloride 
• 501-52-0 3-Phenylpropionic acid 
• 1615-02-7 p-chlorocinnamic acid 
• 7116-36-1 ethyl 3-(4-chlorophenyl)propanoate 
• 104-88-1 4-chlorobenzaldehyde 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 

Downstream Products

• 17052-48-1 3-(4-Chloro-phenyl)-N-(3,4-dimethoxy-benzyl)-propionamide 
• 74631-92-8 ethyl 5-(p-chlorophenyl)-3-oxovalerate 
• 3251-34-1 1-(2-Ethyl-4,5-dimethoxy-phenyl)-3-(4-chlor-phenyl)-propanon-⁽¹⁾ 
• 913837-07-7 N-cyclopropylmethyl-14β-[3-(4-chlorophenyl)propanamido]-7,8-dihydronorcodeinone ethylene glycol ketal 
• 913837-09-9 N-cylopropylmethyl-14β-[3-(4-chlorophenyl)propanamido]-7,8-dihydronorcodeinone 
• 117240-07-0 2(3(4'-chlorophenyl)propionyl)cyclohexanone 
• 940639-28-1 C₁₅H₁₃BrClNO 
• 139377-25-6 (4R,5S)-4-chloro-1-<3-oxo-3-(2-oxo-4-methyl-5-phenyl-3-oxazolidinyl)propyl>benzene 
• 1190732-34-3 N-(4,4-diethoxybutyl)-3-(4-chloro-phenyl)propionamide 
• 1319744-32-5 3-(4-chlorophenyl)-N-(quinolin-8-yl)propanamide 
• 1332701-43-5 ethyl 6-chloro-3-(3-(4-chlorophenyl)propanoyl)-1H-indole-2-carboxylate 

Relevant articles and documents

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Visible-Light Induced C(sp2)?H Amidation with an Aryl–Alkyl σ-Bond Relocation via Redox-Neutral Radical–Polar Crossover

We report an approach for the intramolecular C(sp2)?H amidation of N-acyloxyamides under photoredox conditions to produce δ-benzolactams with an aryl-alkyl σ-bond relocation. Computational studies on the designed reductive single electron transfer strategy led us to identify N-[3,5-bis(trifluoromethyl)benzoyl] group as the most effective amidyl radical precursor. Upon the formation of an azaspirocyclic radical intermediate by the selective ipso-addition with outcompeting an ortho-attack, radical–polar crossover was then rationalized to lead to the rearomative ring-expansion with preferential C?C bond migration.

Cyclohexyl-Fused, Spirobiindane-Derived, Phosphine-Catalyzed Synthesis of Tricyclic ?3-Lactams and Kinetic Resolution of ?3-Substituted Allenoates

A C2-symmetric chiral phosphine catalyst, NUSIOC-Phos, which can be easily derived from cyclohexyl-fused spirobiindane, was introduced. A highly enantioselective domino process involving pyrrolidine-2,3-diones and γ-substituted allenoates catalyzed by NUSIOC-Phos has been disclosed. Diastereospecific tricyclic γ-lactams containing five contiguous stereogenic centers were obtained in high yields and with nearly perfect enantioselectivities. A kinetic resolution process of racemic γ-substituted allenoates was developed for the generation of optically enriched chiral allenoates.