52087-30-6Relevant academic research and scientific papers
Prostaglandins Part 7. Synthesis of (+/-)-11-Deoxy-10-hydroxy- and (+/-)-11-Deoxy-10-oxoprostaglandins
Caton, Michael P. L.,Darnbrough, Geoffrey,Parker, Trevor,Peart, Barry J.,Podmore, Michael L.,Threlfall, Terence L.
, p. 319 - 324 (2007/10/02)
The epoxides of 2-alkylcyclopent-2-enones (I) react with acetic acid to give 5-acetoxy-2-alkylcyclopent-2-enones (II) which afford (+/-)-11-deoxy-10-hydroxyprostaglandins via conjugate-addition reactions.The 11-deoxy-10-hydroxyprostaglandin (IXa) readily undergoes base-catalysed autoxidation to the 11-deoxy-10-oxoprostaglandin (XIII).
