52090-25-2Relevant academic research and scientific papers
Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs
Verhasselt, Sigrid,Stevens, Christian V.,Van den broecke, Tom,Bracke, Marc E.,Roman, Bart I.
, p. 2986 - 2989 (2017)
Myosin II is an interesting target for therapeutic intervention, as it is involved in a large number of motility-based diseases. (S)-Blebbistatin is a known micromolar inhibitor of this protein. A new series of (S)-blebbistatin derivatives with a modified
KINESIN INHIBITORS
-
Page/Page column 47, (2009/01/20)
This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated disorder.
