52090-62-7

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrazolo[4,3-b]pyridine, 1-acetyl(9CI) is used as a building block for the synthesis of pharmaceuticals and bioactive molecules. Its unique structure and reactivity allow for the development of novel therapeutic agents with potential applications in various medical fields.
Used in Medicinal Chemistry Research:
As a promising candidate in medicinal chemistry, 1H-Pyrazolo[4,3-b]pyridine, 1-acetyl(9CI) is used for the development of new chemical entities with diverse biological activities. Its structure provides a foundation for the preparation of chemical derivatives that can be explored for their potential therapeutic effects.
Used in Organic Synthesis:
Due to its unique structure and reactivity, 1H-Pyrazolo[4,3-b]pyridine, 1-acetyl(9CI) is utilized in organic synthesis for the preparation of a variety of chemical compounds. Its versatility as a synthetic intermediate contributes to the creation of new molecules with potential applications in various industries.
Used in Materials Science:
1H-Pyrazolo[4,3-b]pyridine, 1-acetyl(9CI) may also find applications in materials science, where its unique structural features can be leveraged to develop new materials with specific properties. Its potential use in this field is attributed to its ability to form diverse chemical derivatives that can be tailored for specific applications.

Upstream product

• 3430-10-2 2-methyl-3-pyridinamine 
• 127-08-2 potassium acetate 
• 108-24-7 acetic anhydride 
• 34050-39-0 N-(2-methyl-pyridin-3-yl)-acetamide 

Downstream Products

• 272-52-6 1H-pyrazolo-[4,3-b]-pyridine 
• 3054-47-5 N⁵-((R)-3-(acetylthio)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine 

Relevant academic research and scientific papers

Ligand isomerism fine-tunes structure and stability in zinc complexes of fused pyrazolopyridines

Fused-ring pyrazoles offer a versatile platform for derivitization to give finely tuned and functional ligands in coordination assemblies. Here, we explore the pyrazolo[4,3-b]pyridine (HL1) and pyrazolo[3,4-c]pyridine (HL2) backbones and their N-substituted derivatives, using their coordination chemistry with zinc(ii) in the solid state and in solution to examine the steric and electronic effects of varying their substitution pattern. The parent heterocycles HL1 and HL2 both generate robust and permanently porous isomeric MOFs on reaction with zinc and a dicarboxylate co-ligand. The subtle geometric change offered by the position of the backbone pyridyl nitrogen atom leads to substantial changes in the pore size and total pore volume, which is reflected in both their surface areas and CO2 uptake performance. Both materials are also unusually resilient to atmospheric water vapour by virtue of the strong metal–azolate bonding. The isomeric chelating ligands L3–L6, generated by N-arylation of the parent heterocycles with a 2-pyridyl group, each coordinate to zinc to give either mononuclear or polymeric coordination compounds depending on the involvement of the backbone pyridine nitrogen atom. While crystal packing influences based on the steric preferences of the ligands are dominant in the crystalline phase, fluorescence spectroscopy is used to show that the 2H isomers L4 and L6 show distinct coordination behaviour to the 1H isomers L3 and L5, forming competing [ML] and [ML2] species in soution. The first stability constant for L6 with zinc(ii) is an order of magnitude larger than for the other three ligands, suggesting an improved binding strength based on the electron configuration in this isomer. These results show that careful control of remote substitution on fused pyrazole ligands can lead to substantial improvements in the stability of the resulting complexes, with consequences for the design of stable coordination assemblies containining labile metal ions.

Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis

Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.

PYRROLOPYRAZINE KINASE INHIBITORS

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X-Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).