521087-25-2

Upstream product

• 2067-33-6 5-bromopentanoic acid 
• 521087-16-1 2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel 
• 521087-18-3 2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel 
• 342613-14-3 2'-O-(tert-butyldimethylsilyl)docetaxel 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 114915-20-7 Docetaxel 
• 994-30-9 triethylsilyl chloride 

Downstream Products

• 521087-32-1 C₅₉H₉₇NO₁₃SSi₃ 

Relevant academic research and scientific papers

Synthesis of novel 2-O,3′-N-linked macrocyclic taxoids with variable ring size

A series of macrocyclic taxoids was prepared by connecting the 2-OH and 3′-NH moieties with aliphatic chains to mimic the docetaxel solid-state conformation. The synthesis was achieved by acylation of both positions with various bromoalkanoic acids, and ring closure was carried out with sodium sulfide. Nine 19- to 27-membered macrocyclic taxoids were obtained and evaluated as inhibitors of microtubule disassembly as well as for their cytoxicity. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.