521098-00-0Relevant academic research and scientific papers
Amano PS-catalysed enantioselective acylation of (±)-α-methyl-1,3-benzodioxole-5-ethanol: An efficient resolution of chiral intermediates of the remarkable antiepileptic drug candidate, (-)-talampanel
Easwar, Srinivasan,Argade, Narshinha P.
, p. 333 - 337 (2003)
(S)-(+)-α-Methyl-1,3-benzodioxole-5-ethanol 5 is a chiral building block in the synthesis of the future drug (-)-talampanel 1. Amano PS-induced enantioselective acylation of (±)-3 at 50°C using vinyl acetate as acyl donor furnished (+)-5 in 53% yield and
