521097-97-2

Usage

Uses

Used in Pharmaceutical Research:
Safrole alcohol is utilized as a research compound for its pharmacological properties, with the aim of developing new drugs that can harness its potential benefits while mitigating its health risks.
Used in Synthesis of MDMA:
Although its use in this context is illegal and poses significant health risks, safrole alcohol is a precursor in the synthesis of the recreational drug MDMA (ecstasy).

Upstream product

• 108-05-4 vinyl acetate 
• 6974-61-4 β-oxy-α-(3',4'-methylenedioxyphenyl)propane 

Downstream Products

• 521098-00-0 4-Nitro-benzoic acid (S)-2-benzo[1,3]dioxol-5-yl-1-methyl-ethyl ester 
• 379733-75-2 (5S,7R)-7-methyl-5-(4-nitrophenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isochromene 
• 172542-26-6 (S)-α-methyl-1,3-benzodioxole-5-ethanol 

Relevant academic research and scientific papers

Kinetic and chemical resolution of different 1-phenyl-2-propanol derivatives

Seven chiral target molecules containing a hydroxy group have been resolved by both biocatalytic and chemical means. The lipase-catalyzed acylation mainly yielded the acylated derivative of the (R)-alcohols with moderate enantiomeric excess and the enantiopure (S)-alcohols. In the course of the chemical resolution, first the dicarboxylic acid monoesters of the target molecules were synthesized and the resolution of these monoesters was attempted by different homochiral bases. By re-resolution and/or optimization of the reaction time and/or recrystallization, respectively, each molecule was produced in very high enantiomeric purity.

Amano PS-catalysed enantioselective acylation of (±)-α-methyl-1,3-benzodioxole-5-ethanol: An efficient resolution of chiral intermediates of the remarkable antiepileptic drug candidate, (-)-talampanel

(S)-(+)-α-Methyl-1,3-benzodioxole-5-ethanol 5 is a chiral building block in the synthesis of the future drug (-)-talampanel 1. Amano PS-induced enantioselective acylation of (±)-3 at 50°C using vinyl acetate as acyl donor furnished (+)-5 in 53% yield and