5212-68-0Relevant academic research and scientific papers
2-TOSYLOXYMETHYLCYCLANONES: RING SIZE DEPENDENCE OF FRAGMENTATION VERSUS INTRAMOLECULAR ALKYLATION
Heinz, Uwe,Adams, Elisabeth,Klintz, Ralf,Welzel, Peter
, p. 4217 - 4230 (2007/10/02)
The results reported seem to indicate, that in the presence of a nucleophilic base intramolecular alkylation is the normal reaction mode of tosyloxymethylcyclanones of type 14 and that the fragmentation reaction of five-membered compounds is the exception, probably because of the high steric energy of the alkylation transition states, e.g. of type E.
