52123-16-7

Upstream product

• 6068-28-6 tosylate de n-hexadecyle 
• 90-02-8 salicylaldehyde 
• 112-82-3 hexadecanyl bromide 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 4860-03-1 1-Chlorohexadecan 

Downstream Products

• 927814-13-9 C₃₀H₄₃NO₄ 
• 1258682-51-7 N,N'-bis(4-(4'-n-hexadecyloxy)salicylidene)-4-methyl-1,2-phenylenediamine 
• 1287262-69-4 N,N'-bis(4-(4'-n-hexadecyloxy)salicylidene)-1,2-phenylenediamine 
• 1333074-11-5 C₂₉H₄₂ClNO₂ 
• 1333074-08-0 C₃₀H₄₅NO₃ 
• 1248354-34-8 C₂₉H₄₃NO₂ 
• 1333074-10-4 C₂₉H₄₂FNO₂ 
• 1354652-24-6 N,N'-bis(4-(4'-n-hexadecyloxy)salicylidene)-4-nitro-1,2-phenylenediamine 
• 1609246-34-5 N-(4-n-hexadecyloxysalicylidene)-4'-n-octadecyloxyaniline 

Relevant academic research and scientific papers

Directing self-assembly in solution towards improved cooperativity in Fe(iii) complexes with amphiphilic tridentate ligands

An amphiphilic iron(iii) complex with a tridentate Schiff-base ligand was prepared by condensation of a hexadecyloxy functionalised salycylaldehyde with a diamine followed by complexation with FeCl2 and anion methathesis with NaClO4.

Novel tris-buffer based Schiff base bearing long flexible alkoxy arm and its lanthanide complexes: Mesomorphism and photoluminescence

A new liquid crystalline salicylaldimine Schiff base having pendant hydroxymethyl (–CH2OH) groups and a series of lanthanide(III) complexes of the type, [Ln(LH)3(NO3)3] {Ln = La, Pr, Sm, Gd, Tb; LH=(E)-2-((1, 3-

The influence of molecular flexibility on the mesogenic behavior of a new homologous series based on azo-azomethine: Synthesis, characterization, photoisomerization and DFT study

Through condensation of 2-hydroxy-4-n-alkoxybenzaldehyde (n = 2 to 8, 10, 12, 14, 16, 18) with (E)-4-((2,4-dimethylphenyl)diazenyl) benzene-1,3-diamine, new homologous series of rod shaped calamite liquid crystals based on azo-azomethine have been prepared. All synthesized compounds were characterized by FT-IR, 1H NMR, and 13C NMR spectroscopy. Use Differential Scanning Calorimeter (DSC) and Polarizing Optical Microscope (POM) to check the liquid crystal properties of all synthetic compounds. In the homologous series, all the compounds are mesogenic; some of them are in the nematic phase; some of them appear in the smectic A phase, and some appear in the nematic and smectic A phases. UV–vis pectroscopy was used to study the photoisomerization in chloroform. DFT (Density functional theory) level calculations and complete geometric optimization of all synthetic compounds are performed using B3LYP/6-31+G (d, p) basis sets.

Synthesis, characterization, and mesomorphic properties of some new Schiff base homologues series and their Cu(II) complexes

In present study, we have synthesized two homologous series of some new Schiff base of 4-n-alkoxy-2-hydroxy benzaldehyde (n = 2–8, 10, 12, 14, 16, 18) with 4-amino acetanilide and their corresponding Cu(II) complexes. A series of new Schiff base containing two aromatic rings have been synthesized and characterized by various spectroanalytical techniques including FT-IR and 1H NMR. The mesomorphic properties of these compounds were observed by optical polarized light microscopy (POM) and confirmed by differential scanning calorimetry (DSC) study. It has been observed that all the newly synthesized compounds exhibit wide range SmA phase.

Polarization effect in luminescent mesogenic BF2 complexes derived from heterocyclic benzothiazoles

Two series of benzo(thia)xazoles 1–2 and one series of boron difluoride complexes 2-BF2 derived from benzothiazoles 2 were reported, and their mesomorphic and optical properties were investigated. The crystal and molecular structures of compound 2 and 2-BF2 (all n = 8) were determined by means of X?ray structural analysis, and both crystallize in the triclinic P-1 and monoclinic P21/c. The geometry at boron center is perfectly tetrahedral, and the overall molecular shapes are considered as rod?shape. Both benzo(thia)xazoles 1 and 2 exhibited N or/and SmC phase, and boron complexes 2-BF2 formed N or/and SmC phase. Benzothiazoles 2 showed a much wider temperature range of mesophase than those of benzoxazoles 1, which were attributed to the better polarization by sulfur atom incorporated. Boron complexes 2-BF2 (n = 10, 12) emitted a yellow?to?green emission at λmax = 569–571 nm in CH2Cl2. This is the first mesogenic BF2 complexes derived from benzothiazoles.

Chiral Bent-Shaped Molecules Exhibiting Unusually Wide Range of Blue Liquid-Crystalline Phases and Multistimuli-Responsive Behavior

Recently, an unprecedented observation of polar order, thermochromic behavior, and exotic mesophases in new chiral, bent-shaped systems with a ?CH3 moiety placed at the transverse position of the central core was reported. Herein, a homologous series of compounds with even-numbered carbon chains from n=4 to 18 were synthesized, in which ?Cl was substituted for ?CH3 at the kink position and a drastic modification in the phase structure of the bent-shaped molecule was observed. An unusual stabilization of the cubic blue phase (BP) over a wide range of 16.4 °C has been witnessed. Two homologues in this series (1-12 and 1-14) exhibit an interesting phase sequence consisting of BPI/II, chiral nematic, twist grain boundary, smectic A, and smectic X (SmX) phases. The higher homologues (1-16 and 1-18) stabilize the SmX phase enantiotropically over the entire temperature range. Crystal structure analysis confirmed the bent molecular architecture, with a bent angle of 148°, and revealed the presence of two different molecular conformations in an asymmetric unit of compound 1-4. A DFT study corroborated that the ?Cl moiety at the central core of the molecule led to an increase in the dipole moment along the transverse direction, which, in turn, facilitated the unusual stabilization of frustrated structures. Crystal polymorphism has been evidenced in three homologues (1-10, 1-12, and 1-14) of the series. On the application of mechanical pressure through grinding, compound 1-10 transformed from a bright yellow crystalline solid to a dark orange–green amorphous solid, which reversed upon dropwise addition of dichloromethane, indicating reversible mechanochromism in this class of compounds. In addition, excellent thermochromic behavior has been observed for compound 1-10 with a controlled temperature–color combination.

Evaluation of a Series of Lipidated Tucaresol Adjuvants in a Hepatitis C Virus Vaccine Model

Hepatitis C virus (HCV) infections represent a global health challenge; however, developing a vaccine for treatment of HCV infection has remained difficult as heterogeneous HCV contains distinct genotypes, and each genotype contains various subtypes and different envelope glycoproteins. Currently, there is no effective preventive vaccine for achieving global control over HCV. In our efforts to improve upon current HCV vaccines we designed a synthetically accessible adjuvant platform, wherein we synthesized 11 novel lipidated tucaresol analogues to assess their immunological potential. Using a tucaresol-based adjuvant approach, truncated lipid-variants together with an engineered E1E2 antigen construct, namely E2ΔTM3, elicited antibody (Ab) responses that were significantly higher than tucaresol. In sum, antibody end-point titer values largely corroborated HCV neutralization data with a simplified lipidated tucaresol variant affording the highest end point titer and % neutralization. This study lays the groundwork for additional permutations in tucaresol adjuvant design, including the examination of other proteins in vaccine development.

Schiff base of 4-n-alkoxy-2-hydroxy benzaldehyde with 4-amino acetophenone and their Cu(II) complexes: synthesis, characterization and mesomorphic behavior

New homologous series of Schiff’s base of 4-n-Alkoxy-2-hydroxy benzaldehyde (n = 2 to 8, 10, 12, 14, 16, 18) with 4-amino acetophenone and their Cu(II) metal complexes have been synthesized. The compounds were characterized using various spectroscopic techniques including FT-IR, 1H-NMR, 13C-NMR. Mesomorphic properties of these compounds have been investigated with polarizing optical microscope and differential scanning calorimeter. These compounds exhibit wide range SmA phase as confirmed by their typical optical texture under polarizing microscope.

Luminescent mesogenic borondifluoride complexes with the Schiff bases containing salicylideneamines and β-enaminoketones core systems

Three new families of borondifluoride complexes 1a–c derived from salicylideneamines 2a and β-enaminoketonates 2b–c were reported, and their mesomorphic and optical properties were also investigated. One single crystal and molecular structure of nonmesogenic BF2 complex 1c (n = 10) was resolved and the geometry of the central boron atom was tetrahedron. A larger dihedral angle of 81.3° between the two phenyl rings observed in crystal lattice was attributed to the lack of liquid crystallinity. Boron complexes 1a formed monotropic SmA phases, while boron complexes 1b exhibited enantiotropic SmC mesophases. The optical property of the boron complexes was dependent on their molecular structures, and they emitted a blue–to–green emission at λmax = 476–541 nm in the solution and 488–550 nm in the solid state. This is the first group of mesogenic BF2 complexes with the Schiff bases derived from respective salicylideneamines and β-enaminoketones.

Observation of polar order and thermochromic behaviour in a chiral bent-core system exhibiting exotic mesophases due to superstructural frustration

A new approach accompanied by superstructural frustration is reported. By attaching a cholesterol moiety directly to the central bent-core system it displayed exotic BPIII, BPII/I, Ncyb?, TGBA, SmAPA, SmA and SmX phases as shown by X-ray scattering results. While higher homologues of the series exhibited spontaneous formation of polar order (Ps ～ 61 nC cm-2) upon applied voltage, the lower homologues showed thermochromic behaviour which can also be trapped via temperature quenching.