6068-28-6Relevant academic research and scientific papers
Preparation method of higher fatty alcohol 2-alkoxy ethanol
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Paragraph 0030; 0043-0044, (2021/08/25)
The invention provides a preparation method of higher fatty alcohol 2-alkoxy ethanol, and relates to the technical field of organic synthesis, higher fatty alcohol and sulfonyl halide are used as raw materials for cascade reaction, the higher fatty alcohol is completely converted into sulfonate under the action of alkali, and then the sulfonate is subjected to phase transfer reaction under the promotion of a phase transfer catalyst (the used phase transfer catalyst comprises quaternary ammonium salt or crown ether), sulfonate directly performs nucleophilic substitution reaction with ethylene glycol, and the reaction temperature is controlled to complete the reaction within half an hour to obtain the corresponding higher fatty alcohol 2-alkoxy ethanol. The method is low in raw material and reagent cost, simple in process operation, small in pollution, high in product yield and purity, and suitable for large-scale preparation.
NOVEL HYDROXYBUTYRIC ACID ESTER
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Paragraph 0014, (2019/12/11)
PROBLEM TO BE SOLVED: To provide a novel 3HB ester that exhibits a cell activation effect in place of 3HB. SOLUTION: The present invention provides a novel hydroxybutyric acid ester represented by the following chemical formula, where n=8 (3HB stearoyl es
HUMAN NORMAL CELL ACTIVATOR
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Paragraph 0019, (2019/12/12)
PROBLEM TO BE SOLVED: To provide a human normal cell activator. SOLUTION: The present invention provides a human normal cell activator containing at least one selected from the following 3-hydroxy butyric acid alkyl esters, where R is one selected from li
HYDROXYALKANOIC ACID ESTER AND RESIN COMPOSITION CONTAINING THE SAME
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Paragraph 0066-0067, (2019/12/15)
PROBLEM TO BE SOLVED: To provide a novel ester compound from biomass useful as a crystallization promoter for resins; and a resin composition containing the ester compound. SOLUTION: According to the invention, 0.1 to 20 pts.mass of a crystallization prom
Anion-Selective Cholesterol Decorated Macrocyclic Transmembrane Ion Carriers
Behera, Harekrushna,Madhavan, Nandita
supporting information, p. 12919 - 12922 (2017/09/26)
Anion transporters play a vital role in cellular processes and their dysregulation leads to a range of diseases such as cystic fibrosis, Bartter's syndrome and epilepsy. Synthetic chloride transporters are known to induce apoptosis in cancer cell lines. Herein, we report triamide macrocycles that are easily synthesized and externally functionalized by pendant membrane-permeable groups. Among a variety of chains appended onto the macrocycle scaffold, cholesterol is found to be the best with an EC50 value of 0.44 μM. The macrocycle is highly anion-selective and transports ions via an OH-/X- antiport mechanism. The macrocycle is an interesting scaffold for ion-Transport as it is able to discriminate between various anions and shows a preference for SCN- and Cl-. Such anion-selective transporters are highly attractive model systems to study ion-Transport mechanisms and could potentially be of high therapeutic value.
Structure-Activity Relationships of Glucosamine-Derived Glycerolipids: The Role of the Anomeric Linkage, the Cationic Charge and the Glycero Moiety on the Antitumor Activity
Xu, Yaozu,Ogunsina, Makanjuola,Samadder, Pranati,Arthur, Gilbert,Schweizer, Frank
, p. 511 - 520 (2013/08/25)
The potent antitumor activity of 1-O-hexadecyl-2-O-methyl-3-O-(2′-amino-2′-deoxy-β-D-glucopyranosyl)-sn-glycerol (1) was previously shown to arise through an apoptosis-independent pathway. Here, a systematic structure-activity study in which the effects o
Solvent-free and selective tosylation of alcohols and phenols with p-toluenesulfonyl chloride by heteropolyacids as highly efficient catalysts
Fazaeli, Razieh,Tangestaninejad, Shahram,Aliyan, Hamid
, p. 812 - 818 (2007/10/03)
Tosylation of some alcohols and phenols has been directly carried out with p-toluenesulfonyl chloride using heterodoxy acids (H3PW 12O40, H3PMo12O40, A 3PW12O40, and AlPMo12O40) as catalysts in the absence of solvent. We found that heteropoly acids AlPW12O40 and AlPMo 12O40 were effective catalysts for the tosylation of alcohols and phenols. In the case of aliphatic alcohols, secondary alcohols undergo tosylation chemoselectively in the presence of primary hydroxyl groups. This new method consistently has the advantage of excellent yields and short reaction time.
NEW NON-IONIC SURFACTANTS FOR SOLUBILIZING POORLY SOLUBLE MOLECULES
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Page 21-22, (2008/06/13)
New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatty acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene / alkyl polyoxyalkylene chain with a chain-length of 25 - 455 re
ZrCl4 as an efficient catalyst for selective tosylation of alcohols with p-toluenesulfonic acid
Das, Biswanath,Reddy, Vtukuri Saidi
, p. 1428 - 1429 (2007/10/03)
Tosylation of alcohols has directly been carried out with p-toluenesulfonic acid in methylene chloride under reflux using ZrCl4 as a catalyst. Primary alcohols were found to be tosylated chemoselectively over secondary alcohols.
