6068-28-6Relevant articles and documents
Preparation method of higher fatty alcohol 2-alkoxy ethanol
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Paragraph 0030; 0043-0044, (2021/08/25)
The invention provides a preparation method of higher fatty alcohol 2-alkoxy ethanol, and relates to the technical field of organic synthesis, higher fatty alcohol and sulfonyl halide are used as raw materials for cascade reaction, the higher fatty alcohol is completely converted into sulfonate under the action of alkali, and then the sulfonate is subjected to phase transfer reaction under the promotion of a phase transfer catalyst (the used phase transfer catalyst comprises quaternary ammonium salt or crown ether), sulfonate directly performs nucleophilic substitution reaction with ethylene glycol, and the reaction temperature is controlled to complete the reaction within half an hour to obtain the corresponding higher fatty alcohol 2-alkoxy ethanol. The method is low in raw material and reagent cost, simple in process operation, small in pollution, high in product yield and purity, and suitable for large-scale preparation.
HUMAN NORMAL CELL ACTIVATOR
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Paragraph 0019, (2019/12/12)
PROBLEM TO BE SOLVED: To provide a human normal cell activator. SOLUTION: The present invention provides a human normal cell activator containing at least one selected from the following 3-hydroxy butyric acid alkyl esters, where R is one selected from li
Anion-Selective Cholesterol Decorated Macrocyclic Transmembrane Ion Carriers
Behera, Harekrushna,Madhavan, Nandita
supporting information, p. 12919 - 12922 (2017/09/26)
Anion transporters play a vital role in cellular processes and their dysregulation leads to a range of diseases such as cystic fibrosis, Bartter's syndrome and epilepsy. Synthetic chloride transporters are known to induce apoptosis in cancer cell lines. Herein, we report triamide macrocycles that are easily synthesized and externally functionalized by pendant membrane-permeable groups. Among a variety of chains appended onto the macrocycle scaffold, cholesterol is found to be the best with an EC50 value of 0.44 μM. The macrocycle is highly anion-selective and transports ions via an OH-/X- antiport mechanism. The macrocycle is an interesting scaffold for ion-Transport as it is able to discriminate between various anions and shows a preference for SCN- and Cl-. Such anion-selective transporters are highly attractive model systems to study ion-Transport mechanisms and could potentially be of high therapeutic value.