52126-37-1Relevant academic research and scientific papers
A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms
Shi, Shuai,Li, Ruining,Rao, Liangming,Sun, Zhankui
, p. 669 - 672 (2020)
A radical deuteration procedure using D2O as the source of deuterium atoms is strongly preferred in terms of mildness, sustainability, and cost. Herein, we disclose a radical approach for site-specific, highly efficient and metal-free deuteration using D2O under visible light conditions. This desulfurization-deuteration strategy features mild conditions, broad substrate scope, highly efficient D-incorporation, excellent functional group compatibility, sustainable energy and is hardly affected by substrate steric factors.
Method for deuterating organic matter
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Page/Page column 5; 10, (2019/10/01)
The present invention relates to a method of deuterating an organic matter, especially relates to a method of deuterating an organic compound containing a mercapto group or a disulfide bond, and belongs to the technical field of molecular marking. The method of deuterating the organic matter the following steps: dissolving the organic matter in a mixed solvent of an organic solvent and deuterium oxide, adding a phosphine reagent and a free radical initiator, and carrying out a reaction under a light condition for 3-6 h to convert the substrate into a corresponding deuterated product, wherein the organic matter is a thiol, a disulfide or a cysteine-containing polypeptide organic compound. The deuterating method has the characteristics of high deuteration efficiency, good selectivity, good functional group tolerance, high yield, mild reaction conditions, no metals participating in the reaction, wide substrate range and the like, is especially suitable for selectively deuterating the specific position of the carbon chain, and is also suitable for polypeptide substrates.
Palladium-catalyzed coupling reaction of -diazocarbonyl compounds with aromatic boronic acids or halides
Peng, Cheng,Yan, Guobin,Wang, Yan,Jiang, Yubo,Zhang, Yan,Wang, Jianbo
experimental part, p. 4154 - 4168 (2011/02/25)
Efficient palladium-catalyzed cross-coupling reactions of -diazocarbonyl compounds and arylboronic acids or aryl halides have been developed. The reaction proceeds smoothly for a range of diazo compounds, boronic acids, and halides. The coupling reaction conditions tolerate various substituents on the aromatic rings of the substrates, such as chloro, fluoro, acyl, oxo, ester, and nitro groups. This coupling reaction constitutes a novel access to -aryl-substituted ,-unsaturated carbonyl compounds. Mechanistically, palladium-carbene is supposed to be the key intermediate; its formation is followed by migratory insertion of an aryl group to the carbenic carbon of the palladium-carbene complex and subsequent -hydride elimination. Kinetic isotope effect (KIE) data measured for intra- and intermolecular competition experiments suggest that -hydride elimination is not involved in the rate-determining step
