521274-44-2

Upstream product

• 521274-34-0 phenoxy-acetic acid 1-[2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5-[2-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-5-(2-trityloxy-ethyl)-[1,3]dioxolan-4-ylmethyl]-5-[3-(4-methoxy-phenoxymethoxy)-cyclohexyl]-penta-2,4-dienyl ester 
• 521274-32-8 (5S,6S)-6-((E)-2-{(2R,4R,5R)-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-5-((2R,5Z)-2-hydroxy-6-{(1R,3S)-3-[(4-methoxyphenoxy)methoxy]cyclohexyl}hex-5-en-3-ynyl)-4-[2-(trityloxy)ethyl]-[1,3]dioxolan-4-yl}vinyl)-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 521274-33-9 (5S,6S)-6-{(E)-2-[(2R,4R,5R)-2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-{(3Z,5Z)-(R)-2-hydroxy-6-[(1R,3S)-3-(4-methoxy-phenoxymethoxy)-cyclohexyl]-hexa-3,5-dienyl}-4-(2-trityloxy-ethyl)-[1,3]dioxolan-4-yl]-vinyl}-5-ethyl-5,6-dihydro-pyran-2-one 
• 1053731-78-4 (R)-3-{(E)-(2R,3S)-5-[(2R,4R,5R)-5-Allyl-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2-trityloxy-ethyl)-[1,3]dioxolan-4-yl]-2-ethyl-3-triethylsilanyloxy-pent-4-enoyl}-4-benzyl-oxazolidin-2-one 
• 521274-27-1 (R)-3-{(E)-(2R,3S)-5-[(2R,4R,5R)-5-Allyl-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-(2-trityloxy-ethyl)-[1,3]dioxolan-4-yl]-2-ethyl-3-hydroxy-pent-4-enoyl}-4-benzyl-oxazolidin-2-one 
• 521274-41-9 S-ethyl (4E,7R)-7-C-allyl-6,7-O-(4-{[tert-butyl(dimethyl)silyl]oxy}benzylidene)-2,4,5-trideoxy-2-ethyl-1-thio-3-O-(triethylsilyl)-6-C-[2-(trityloxy)ethyl]-L-arabino-4-enoate 
• 521274-28-2 ethyl (2Z,4S,5S,6E)-7-{(2R,4R,5R)-5-allyl-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-[2-(tritylioxy)ethyl]-[1,3]dioxolan-4-yl}-4-ethyl-5-hydroxyhepta-2,6-dienoate 
• 521274-42-0 (5S,6S)-6-((E)-2-{(2R,4R,5R)-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-5-(2,3-dihydroxypropyl)-4-[2-(trityloxy)ethyl]-[1,3]dioxolan-4-yl}vinyl)-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 521274-25-9 (2R,4R,5R)-5-Allyl-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-4-((E)-3-triisopropylsilanyloxy-propenyl)-4-(2-trityloxy-ethyl)-[1,3]dioxolane 
• 521274-29-3 (5S,6S)-6-((E)-2-{(2R,4R,5R)-5-allyl-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-[2-(trityloxy)ethyl]-[1,3]dioxolan-4-yl}vinyl)-5-ethyl-5,6-dihydro-2H-pyran-2-one 
• 521274-30-6 [(2R,4R,5R)-2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-5-[(E)-2-((2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-5-(2-trityloxy-ethyl)-[1,3]dioxolan-4-yl]-acetaldehyde 
• 521274-26-0 (2E)-3-{(2R,4R,5R)-5-allyl-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-4-[2-(trityloxy)ethyl]-[1,3]dioxolan-4-yl}acrylaldehyde 
• 521274-24-8 (E)-(4R,5R)-8-Triisopropylsilanyloxy-5-(2-trityloxy-ethyl)-octa-1,6-diene-4,5-diol 
• 521274-40-8 4-{(2R,4R,5R)-5-allyl-4-[(1E)-3-hydroxyprop-1-enyl]-4-[2-(trityloxy)ethyl]-[1,3]dioxolan-2-yl}phenol 

Downstream Products

• 145142-82-1 leustroducsin B 
• 521274-48-6 (1S,3R)-3-{(1Z,3Z,5R,7R,8R,9E)-8-(2-{[(allyloxyl)carbonyl]amino}ethyl)-7-{[bis(allyloxy)phosphoryl]oxy}-10-[(2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-5-hydroxy-8-[(trimethylsilyl)oxy]deca-1,3,9-trienyl}cyclohexyl (6S)-6-methyloctanoate 
• 521274-36-2 (1R,2Z,4Z)-1-{(2R,3R,4E)-3-(2-{[(allyloxyl)carbonyl]amino}ethyl)-5-[(2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-2,3-dihydroxypent-4-enyl}-5-{(1R,3S)-3-[(4-methoxyphenoxy)methyl]cyclohexyl}penta-2,4-dienyl phenoxyacetate 
• 521274-45-3 (1R,2Z,4Z)-1-{(2R,3R,4E)-3-(2-{[(allyloxyl)carbonyl]amino}ethyl)-5-[(2S,3S)-3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-2-hydroxy-3-[(trimethylsilyl)oxy]pent-4-enyl}-5-{(1R,3S)-3-[(4-methoxyphenoxy)methyl]cyclohexyl}penta-2,4-dienyl phenoxyacetate 
• 521274-35-1 phenoxy-acetic acid 1-{5-(2-allyloxycarbonylamino-ethyl)-2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5-[2-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-[1,3]dioxolan-4-ylmethyl}-5-[3-(4-methoxy-phenoxymethoxy)-cyclohexyl]-penta-2,4-dienyl ester 
• 521274-46-4 phenoxy-acetic acid 1-[3-(2-allyloxycarbonylamino-ethyl)-2-(bis-allyloxy-phosphoryloxy)-5-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-3-trimethylsilanyloxy-pent-4-enyl]-5-[3-(4-methoxy-phenoxymethoxy)-cyclohexyl]-penta-2,4-dienyl ester 
• 521274-37-3 6-methyl-octanoic acid 3-[8-(2-allyloxycarbonylamino-ethyl)-7-(bis-allyloxy-phosphoryloxy)-10-(3-ethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-5-phenoxyacetoxy-8-trimethylsilanyloxy-deca-1,3,9-trienyl]-cyclohexyl ester 

Relevant academic research and scientific papers

Total synthesis of leustroducsin B

A convergent total synthesis of leustroducsin B (1), which is known to exhibit a variety of biological activities, was successfully carried out. Notable features of our synthesis include construction of the C8 stereocenter by lipase-mediated desymmetrizat