521298-40-8Relevant academic research and scientific papers
Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry
He, Yun,Yang, Jun,Wu, Baogen,Robinson, Dale,Sprankle, Kelly,Kung, Pei-Pei,Lowery, Kristin,Mohan,Hofstadler, Steve,Swayze, Eric E.,Griffey, Rich
, p. 695 - 699 (2004)
A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.
