521306-75-2Relevant academic research and scientific papers
A fluorogenic dye activated by the Staudinger ligation
Lemieux, George A.,De Graffenried, Christopher L.,Bertozzi, Carolyn R.
, p. 4708 - 4709 (2003)
Specific labeling of biomolecules with biochemical and biophysical probes is a central element of proteomics research. Here we describe a coumarin-phosphine dye that undergoes activation of coumarin fluorescence upon Staudinger ligation with azides. Since azides can be metabolically incorporated into cellular proteins and oligosaccharides, this dye may be a useful tool for profiling proteins and their posttranslational modifications. Copyright
