52132-34-0

Basic information

• Product Name: (2E)-5-chloro-2-iminopyridin-1(2H)-ol
• CAS NO: 52132-34-0
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.559
• Mol File: 52132-34-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 199.2°C at 760 mmHg
• Flash Point: 74.3°C
• Density: 1.46g/cm³
• Vapor Pressure: 0.0868mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: (2E)-5-chloro-2-iminopyridin-1(2H)-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-5-chloro-2-iminopyridin-1(2H)-ol(52132-34-0)
• EPA Substance Registry System: (2E)-5-chloro-2-iminopyridin-1(2H)-ol(52132-34-0)

Safety Data

• Hazardous Substances Data: 52132-34-0(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 57097-36-6 2-azido-5-chloro-pyridine 1-oxide 
• 1072-98-6 5-chloro-2-pyridylamine 

Downstream Products

• 244221-57-6 5-chloro-2-iodo-pyridine 

Relevant articles and documents

Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction

The invention provides a ligand compound capable of being used for copper catalyzed aryl halide coupling reaction, the ligand compound is a three-class compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group, and the invention also provides a catalytic system for the aryl halide coupling reaction. Thecatalytic system comprises a copper catalyst, a compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group adopted as a ligand, alkali and a solvent, and meanwhile, the invention also provides a system for the aryl halide coupling reaction adopting the catalyst system. The compound containing the 2-(substituted or non-substituted) aminopyridine nitrogen oxygen group can be used as the ligand for the copper catalyzed aryl chloride coupling reaction, and the ligand is stable under a strong alkaline condition and can well maintain catalytic activity when being used for the copper-catalyzed aryl chloride coupling reaction. In addition, the copper catalyst adopting the compound as the ligand can particularly effectively promote coupling of copper catalyzed aryl chloride and various nucleophilic reagents which are difficult to generate under conventional conditions, C-N, C-O and C-S bonds are generated, and numerous useful small molecule compounds are synthesized. Therefore, the aryl halide coupling reaction has a very good large-scale application prospect by adopting the copper catalysis system of the ligand.

Tandem Condensation/Rearrangement Reaction of 2-Aminohetarene N-Oxides for the Synthesis of Hetaryl Carbamates

A new approach to hetaryl carbamates through a tandem condensation/rearrangement reaction of 2-aminohetarene N-oxides was developed. The developed reaction is suitable for both five- and six-membered heterocycles and proceeds through the condensation of 2

Tricyclic Compounds As mPGES-1 Inhibitors

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.