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52132-61-3

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52132-61-3 Usage

General Description

3,5-Dinitro-4-hydroxybenzaldehyde is a chemical compound with the molecular formula C7H4N2O7. It is a yellow solid that is commonly used as a reagent in organic synthesis and as a precursor for various other compounds. It is known for its strong odor and is considered to be hazardous if inhaled or ingested. 3,5-Dinitro-4-hydroxybenzaldehyde is commonly used in the production of pharmaceuticals, dyes, and other organic compounds. It is also used in the synthesis of pesticides and herbicides. Due to its potential hazards, it is important to handle this chemical with care and follow proper safety procedures when working with it.

Check Digit Verification of cas no

The CAS Registry Mumber 52132-61-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,1,3 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 52132-61:
(7*5)+(6*2)+(5*1)+(4*3)+(3*2)+(2*6)+(1*1)=83
83 % 10 = 3
So 52132-61-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H4N2O6/c10-3-4-1-5(8(12)13)7(11)6(2-4)9(14)15/h1-3,11H

52132-61-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-hydroxy-3,5-dinitrobenzaldehyde

1.2 Other means of identification

Product number -
Other names Benzaldehyde,4-hydroxy-3,5-dinitro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52132-61-3 SDS

52132-61-3Relevant articles and documents

Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases

Greer, Aleksandra K.,Madadi, Nikhil R.,Bratton, Stacie M.,Eddy, Sarah D.,Mazerska, Zofia,Hendrickson, Howard P.,Crooks, Peter A.,Radominska-Pandya, Anna

, p. 536 - 545 (2014/05/06)

Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs which would be glucuronidated at a lower rate than tRes itself. In this work, three synthetic stilbenoids, (E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylic acid (NI-12a), (E)-2,4-dimethoxy-6-(4-methoxystyryl)benzaldehyde oxime (NI-ST-05), and (E)-4-(3,5-dimethoxystyryl)-2,6-dinitrophenol (DNR-1), have been designed based on the structure of tRes and synthesized in our laboratory. UGTs recognize and glucuronidate tRes at each of the 3 hydroxyl groups attached to its aromatic rings. Therefore, each of the above compounds was designed with the majority of the hydroxyl groups blocked by methylation and the addition of other novel functional groups as part of a drug optimization program. The activities of recombinant human UGTs from the 1A and 2B families were examined for their capacity to metabolize these compounds. Glucuronide formation was identified using HPLC and verified by β-glucuronidase hydrolysis and LC-MS/MS analysis. NI-12a was glucuronidated at both the -COOH and -OH functions, NI-ST-05 formed a novel N-O-glucuronide, and no product was observed for DNR-1. NI-12a is primarily metabolized by the hepatic and renal enzyme UGT1A9, whereas NI-ST-05 is primarily metabolized by an extrahepatic enzyme, UGT1A10, with apparent Km values of 240 and 6.2 μM, respectively. The involvement of hepatic and intestinal UGTs in the metabolism of both compounds was further confirmed using a panel of human liver and intestinal microsomes, and high individual variation in activity was demonstrated between donors. In summary, these studies clearly establish that modified, tRes-based stilbenoids may be preferable alternatives to tRes itself due to increased bioavailability via altered conjugation.

Trichloroisocyanuric Acid/NaNO2/wet SiO2 as an Efficient System for the Selective Dinitration of Phenols under Solvent-free Conditions

Zolfigol, Mohammad Ali,Madrakian, Elaheh,Ghaemi, Ezat

, p. 2222 - 2224 (2007/10/03)

Dinitrophenols can be obtained via direct nitration of phenols with trichloroisocyanuric acid, NaNO2 and wet SiO2 at room temperature under solvent-free conditions with moderate to high yields.

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