52143-73-4

Upstream product

• 1635-61-6 5-chloro-2-nitroaniline 
• 106-45-6 para-thiocresol 

Downstream Products

• 620604-38-8 4-(4-methylphenylsulphonyl)-2-chloroaniline 
• 59011-29-9 N-[2-Amino-5-(toluene-4-sulfinyl)-phenyl]-butyramide 
• 59011-20-0 N-(2-Amino-5-p-tolylsulfanyl-phenyl)-butyramide 

Relevant academic research and scientific papers

Chemical compounds and their use to elevate pyruvate dehydrogenase activity

The use of a compound of the formula (I): wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A—B is selected from NHCO, OCH2, SCH2, NHCH2, trans-vinylene, and ethynylene; R1is linked to ring C at a carbon ortho to the position of A—B attachment and is defined herein; n is 1 or 2; R2and R3are alkyl, haloalkyl or together from cycloalkyl or halocycloalkyl as defined herein; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Salts and esters of compounds of formula (I) are also described.

Substituted (alkoxycarbonylthioureido)-(acylamino)-benzene derivatives

Benzene derivatives of the formula: STR1 wherein R1 represents alkyl, R2 represents a group --SR3, --SOR3, --SO2 R3, --OR3, --SCONH2, --SCN or --T(CH2)m T1 R4 [wherein R3 represeents alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, unsubstituted or substituted aryl, or cycloalkylalkyl, R4 represents hydrogen or alkyl, T and T1 each represent oxygen, sulphur or sulphinyl, and m is an integer from 1 to 7] whose position on the benzene ring is either para to the group --NHCSNHCOOR1 or para to the group --NHCOAZ, A represents a bivalent straight-chain aliphatic hydrocarbon radical of 1 to 4 carbon atoms or a said hydrocarbon radical substituted by at least one methyl group, and Z represents a group of the formula:- STR2 wherein R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl or phenylalkyl, and R7 represents hydrogen or alkyl, or R6 and R7 together with the nitrogen atom to which they are attached form a 5-,6- or 7-membered heterocyclic ring optionally substituted by alkyl group(s), and X- represents a pharmaceutically acceptable anion, are new compounds useful as anthelmintics and antifungal agents.