620604-38-8Relevant academic research and scientific papers
Photo-Fries rearrangement of N-arylsulfonamides to aminoaryl sulfone derivatives
Park, Kwanghee Koh,Lee, Jin Joo,Ryu, Jaegyung
, p. 7651 - 7659 (2003)
Photochemical reaction of variously substituted p-toluenesulfonanilides was studied. The reaction gives rearranged products, o- and p-amino-substituted diaryl sulfones with the combined yields of 38-72%: the p-isomer is more favored over the o-isomer with the selectivity ratio of 1.1-4.3 depending on the substituents. N-Alkylation of the sulfonanilides increases the yields of the rearranged products, and e-withdrawing substituents on the N-phenyl ring does not lower the yields drastically. This study provides simple methodology for the synthesis of o- and p-aminoaryl sulfones which are otherwise not easily accessible.
Chemical compounds and their use to elevate pyruvate dehydrogenase activity
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, (2008/06/13)
The use of a compound of the formula (I): wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A—B is selected from NHCO, OCH2, SCH2, NHCH2, trans-vinylene, and ethynylene; R1is linked to ring C at a carbon ortho to the position of A—B attachment and is defined herein; n is 1 or 2; R2and R3are alkyl, haloalkyl or together from cycloalkyl or halocycloalkyl as defined herein; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Salts and esters of compounds of formula (I) are also described.
