52148-00-2

Upstream product

• 52147-97-4 trans 2-phenylethenesulfonyl chloride 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 555-16-8 4-nitrobenzaldehdye 
• 639008-17-6 2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester 
• 100-13-0 4-nitrostyrene 

Downstream Products

• 110417-49-7 4-[(E)-2-(4-Nitro-phenyl)-ethenesulfonyl]-morpholine 
• 110417-48-6 (E)-2-(4-Nitro-phenyl)-ethenesulfonic acid dimethylamide 
• 639008-01-8 2-(4-nitrophenyl)ethenesulfonic acid benzylmethylamide 
• 52147-74-7 N-(4-nitrostyrylsulfonyl)acetamidine 
• 52147-75-8 N-(4-nitrostyrylsulfonyl)benzamidine 

Relevant academic research and scientific papers

Green approach for the synthesis of thiophenyl pyrazoles and isoxazoles by adopting 1,3-dipolar cycloaddition methodology and their antimicrobial activity

A variety of N-((1,3-diphenyl-5-aryl-1H-pyrazol-4-yl)sulfonyl)thiophene-2-carboxamides (7) and N-((5-aryl-3-phenylisoxazol-4-yl)sulfonyl)thiophene-2-carboxamides (8) were prepared from (E)-N-(arylethenesulfonyl)thiophene-2-carboxamides (4) adopting 1,3-di

Synthesis of 5-substituted indole derivatives. Part 4: Naratriptan from α-anilinoacetaldehyde dimethylacetal by TiCl4-mediated cyclisation

N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide (Naratriptan, 2) was prepared from N-methyl-N-phenylmethyl-2-(4-aminophenyl)-ethanesulfonamide (3b) through reductive alkylation with dimethoxyacetaldehyde followed by N-acylation and TiCl4-mediated indolisation, according to Sundberg procedure. The isopropyl group proved to be a useful protecting group for sulfonate esters in a number of transformations but was cleaved in the presence of TiCl4.

Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases

Based on a previously identified lead structure, SC-ααδ9, we have developed a versatile new chemical scaffold that can be readily modified to generate libraries of both Tyr and dual specificity phosphatase inhibitors with reduced molecular weight and lipophilicity. The most potent analogue identified to date, aminothiazole 8z, inhibits the dual specificity phosphatase Cdc25B with a Ki of 4.6 ± 0.4 μM and a Hill coefficient of 2.

Styrylamidines

Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.