52157-57-0Relevant academic research and scientific papers
HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
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Paragraph 00161, (2015/01/16)
Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.
Pd-catalyzed reaction of aryl halides and propargyl furylmethyl ethers: A novel pathway to functionalized dihydroisobenzofurans
Chen, Lingzhu,Shen, Ruwei,Wu, Luling,Huang, Xian
, p. 5954 - 5962 (2013/09/12)
An interesting sequential reaction involving Sonogashira coupling, propargyl-allenyl isomerization, intramolecular [4 + 2] cycloaddition, and bridged oxa-ring opening has been realized, providing a facile method for the synthesis of functionalized dihydroisobenzofurans from easily accessible starting materials with a decent diastereoselectivity.
DETECTION OF 2,5-DIMETHYLENE-2,5-DIHYDROTHIOPHENE AND THIOPHENORADIALENE
Muenzel, Norbert,Kesper, Karl,Schweig, Armin,Specht, Harald
, p. 6239 - 6242 (2007/10/02)
The reactive species 2,5-dimethylene-2,5-dihydrothiophene and thiophenoradialene have been detected for the first time.The method of HCl elimination has proved to be a generally applicable method for generating heterocyclic xylylenes and radialenes.
