52158-48-2

Usage

Uses

Used in Organic Synthesis:
1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is used as a building block in organic synthesis for the preparation of various chemical compounds. Its fluorinated structure allows for the creation of new molecules with unique properties and potential applications.
Used in Material Development:
Due to its unique structure and fluorine substituents, 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is used as a precursor in the development of new materials with specific properties, such as high thermal stability, chemical resistance, or specific optical characteristics.
Used in Pharmaceutical Industry:
1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is used as an intermediate in the synthesis of pharmaceutical compounds. Its fluorinated structure can potentially enhance the bioactivity, selectivity, or pharmacokinetic properties of the resulting drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is used as a starting material for the synthesis of new agrochemicals, such as pesticides or herbicides, with improved efficacy and selectivity.
Used in Specialty Chemicals Production:
1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is a valuable intermediate for the production of specialty chemicals, which may have specific applications in various industries, such as coatings, adhesives, or polymers.
Used in Research:
Due to its unique structure and properties, 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is used in research for the exploration of new chemical reactions, synthesis methods, and potential applications in various fields.
However, it is important to note that the high level of fluorination in 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde may pose potential risks to the environment and human health. Therefore, proper safety measures should be taken when handling and using 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde to minimize any adverse effects.

Upstream product

• 27041-16-3 1,3,4,5,6,7,8-heptafluoronaphthalene-2-sulfonyl chloride 
• 313-72-4 octafluoronaphthalene 
• 27041-17-4 2-Bromo-1,3,4,5,6,7,8-heptafluoronaphthalene 
• 93-61-8 N-methyl-N-phenylformamide 
• 137676-34-7 1,3,4,5,6,7,8-heptafluoro-2-naphthylmethyl methyl sulphoxide 
• 1150-36-3 (1,3,4,5,6,7,8-heptafluoronaphthalen-2-yl)hydrazine 
• 5461-49-4 N-ethylformanilide 
• 52158-47-1 2-Chloroheptafluoronaphthalene 

Relevant academic research and scientific papers

Utilization of Donor–Acceptor Interactions for the Catalytic Acceleration of Nucleophilic Additions to Aromatic Carbonyl Compounds

A conceptually new method for the catalytic electrophilic activation of aromatic carbonyl substrates, by utilizing donor–acceptor interactions between an electron-deficient macrocyclic boronic ester host ([2+2]BTH-F) and an aromatic carbonyl guest substrate, was realized. In the presence of a catalytic amount of [2+2]BTH-F, dramatic acceleration of the nucleophilic addition of a ketene silyl acetal towards either electron-rich aromatic aldehydes or ketones was achieved. Several control experiments confirmed that inclusion of the aromatic substrates within [2+2]BTH-F, through efficient donor–acceptor interactions, is essential for the acceleration of the reaction.

PARTIALLY FLUORINATED HETEROCYCLIC COMPOUNDS PART 28. THE HYDROLYSIS OF 1,3,4,5,6,7,8-HEPTAFLUORO-2-NAPHTHYLIDENERHODANINE TO FORM RING-FUSED THIOPHENES. A SIGNIFICANT PROPORTION OF A LINEAR NAPHTHOTHIOPHENE DERIVATIVE ACCOMPANYING AN ANGULAR NAPHTHOTHIOPHENE DERIVATIVE

1,3,4,5,6,7,8-Heptafluoronaphthalene-2-carbaldehyde (7), prepared via a Grignard reaction from 2-bromo-1,3,4,5,6,7,8-heptafluoronaphthalene (9) with N-methylformanilide, reacted with rhodanine to give 1,3,4,5,6,7,8-heptafluoro-2-naphthylidenerhodanine (5).Hydrolysis of (5) with base gave a mixture of 4,5,6,7,8,9-hexafluoronaphthopthiophene-2-carboxylic acid (11) and 4,5,6,7,8,9-hexafluoronaphthothiophene-2-carboxylic acid (12) resulting from the intermediate thiolate (6) displacing fluorine at sites 3 and 1 in the naphthalene ring in the ratio 22:78 respectively, which represents a significantly high portion of the linearly cyclised product accompanying the angularly cyclised product.Decarboxylation of the mixture of (11) and (12) gave 4,5,6,7,8,9-hexafluoronaphthothiophene (13) and 4,5,6,7,8,9-hexafluoronaphthothiophene (14) respectively, while treatment of the mixture (11) and (12) with diazomethane gave an inseparable mixture of the methyl 2-carboxylates (15) and (16) respectively.

Partially Fluorinated Heterocyclic Copmpounds. Part 27. The Synthesis of 4,5,6,7-Tetrafluorobenzothiophene and 4,5,6,7,8,9-Hexafluoronaphthothiophene; some Chemistry and Electrochemistry

2,3,4,5,6-Pentafluorobenzyl methyl sulphoxide (6) is readily converted by butyl-lithium into 4,5,6,7-tetrafluorobenzothiophene (8) and 1,3,4,5,6,7,8-heptafluoro-2-naphthylmethyl methyl sulphoxide (9) in a similar manner gives a very low yield of 4,5,6,7,8,9-hexafluoronaphthothiophene (11) accompanied by the 7- and 8-butylated derivatives (12) and (13) respectively, and also 1,3,4,5,6,7,8-heptafluoronaphthalene-2-carbaldehyde (10).Compound (8) undergoes Diels-Alder addition reactions followed by sulphur elimination with dimethyl acetylenedicarboxylate and tetrafluorbenzyne to give the naphthalene and anthracene derivatives (14) and (15) respectively.With lithium propane-2-thiolate, compound (8) gives the 5-propan-2-ylthio and 5,6-bispropan-2-ylthio derivatives (16) and (17) respectively.Compound (8) is polymerised by SbF5-HF to poly(1,3-dihydro-4,5,6,7-tetrafluorobenzo-thiophene) (20).The electrochemical anodic oxidation of (8) has been studied extensively: polymer (20) is produced accompanied by a deep red material readily soluble in chloroform, which is not poly(4,5,6,7-tetrafluorobenzothiophene) (24).