52158-48-2

Basic information

• Product Name: 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde
• Synonyms: 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde
• CAS NO: 52158-48-2
• Molecular Formula: C11HF7O
• Molecular Weight: 282.1138624
• Mol File: 52158-48-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde(52158-48-2)
• EPA Substance Registry System: 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde(52158-48-2)

Safety Data

• Hazardous Substances Data: 52158-48-2(Hazardous Substances Data)

Usage

General Description

1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is a compound with the molecular formula C10H3F7O. It is a naphthaldehyde derivative with seven fluorine atoms attached to the naphthalene ring, and a carbonyl group at position 2. 1,3,4,5,6,7,8-heptafluoro-2-naphthaldehyde is used in organic synthesis and as a building block for the preparation of various chemical compounds. Its unique structure and fluorine substituents make it useful for the development of new materials, pharmaceuticals, and agrochemicals. It is also a valuable intermediate for the production of specialty chemicals and research purposes. However, its high level of fluorination makes it potentially harmful to the environment and human health, and proper safety measures should be taken when handling and using this compound.

Upstream product

• 27041-16-3 1,3,4,5,6,7,8-heptafluoronaphthalene-2-sulfonyl chloride 
• 1150-36-3 (1,3,4,5,6,7,8-heptafluoronaphthalen-2-yl)hydrazine 
• 313-72-4 octafluoronaphthalene 
• 5461-49-4 N-ethylformanilide 
• 52158-47-1 2-Chloroheptafluoronaphthalene 
• 27041-17-4 2-Bromo-1,3,4,5,6,7,8-heptafluoronaphthalene 
• 93-61-8 N-methyl-N-phenylformamide 
• 137676-34-7 1,3,4,5,6,7,8-heptafluoro-2-naphthylmethyl methyl sulphoxide 

Relevant articles and documents

Utilization of Donor–Acceptor Interactions for the Catalytic Acceleration of Nucleophilic Additions to Aromatic Carbonyl Compounds

A conceptually new method for the catalytic electrophilic activation of aromatic carbonyl substrates, by utilizing donor–acceptor interactions between an electron-deficient macrocyclic boronic ester host ([2+2]BTH-F) and an aromatic carbonyl guest substrate, was realized. In the presence of a catalytic amount of [2+2]BTH-F, dramatic acceleration of the nucleophilic addition of a ketene silyl acetal towards either electron-rich aromatic aldehydes or ketones was achieved. Several control experiments confirmed that inclusion of the aromatic substrates within [2+2]BTH-F, through efficient donor–acceptor interactions, is essential for the acceleration of the reaction.

PARTIALLY FLUORINATED HETEROCYCLIC COMPOUNDS PART 28. THE HYDROLYSIS OF 1,3,4,5,6,7,8-HEPTAFLUORO-2-NAPHTHYLIDENERHODANINE TO FORM RING-FUSED THIOPHENES. A SIGNIFICANT PROPORTION OF A LINEAR NAPHTHOTHIOPHENE DERIVATIVE ACCOMPANYING AN ANGULAR NAPHTHOTHIOPHENE DERIVATIVE

1,3,4,5,6,7,8-Heptafluoronaphthalene-2-carbaldehyde (7), prepared via a Grignard reaction from 2-bromo-1,3,4,5,6,7,8-heptafluoronaphthalene (9) with N-methylformanilide, reacted with rhodanine to give 1,3,4,5,6,7,8-heptafluoro-2-naphthylidenerhodanine (5).Hydrolysis of (5) with base gave a mixture of 4,5,6,7,8,9-hexafluoronaphthopthiophene-2-carboxylic acid (11) and 4,5,6,7,8,9-hexafluoronaphthothiophene-2-carboxylic acid (12) resulting from the intermediate thiolate (6) displacing fluorine at sites 3 and 1 in the naphthalene ring in the ratio 22:78 respectively, which represents a significantly high portion of the linearly cyclised product accompanying the angularly cyclised product.Decarboxylation of the mixture of (11) and (12) gave 4,5,6,7,8,9-hexafluoronaphthothiophene (13) and 4,5,6,7,8,9-hexafluoronaphthothiophene (14) respectively, while treatment of the mixture (11) and (12) with diazomethane gave an inseparable mixture of the methyl 2-carboxylates (15) and (16) respectively.