5216-04-6Relevant articles and documents
Ruthenium-Porphyrin-Catalyzed [4 + 2] Cycloaddition of α,β-Unsaturated Imines and Aldehydes
Maeda, Kazuki,Terada, Takuma,Iwamoto, Takahiro,Kurahashi, Takuya,Matsubara, Seijiro
, p. 5284 - 5287 (2015)
A new efficient synthetic route to unsymmetrically substituted dihydropyridine scaffolds via dehydrative [4 + 2] cycloaddition of N-tosylated α,β-unsaturated imines with aldehydes has been developed. This transformation is enabled by (i) the remarkable ca
Intramolecular carbolithiation of N-allyl-ynamides: An efficient entry to 1,4-dihydropyridines and pyridines - Application to a formal synthesis of sarizotan
Gati, Wafa,Rammah, Mohamed M.,Rammah, Mohamed B.,Evano, Gwilherm
, p. 2214 - 2222 (2013/02/23)
We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides. This reaction, which has been successfully applied to the formal synthesis of the anti-dyskinesia agent sarizotan, further extends the use of ynamides in organic synthesis and further demonstrates the synthetic efficiency of carbometallation reactions.
Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin
Chang, Meng-Yang,Lin, Chung-Han,Chen, Yeh-Long
scheme or table, p. 1430 - 1433 (2010/05/03)
Selenium dioxide-mediated methoxyhydroxylation of cyclic arylolefin with the modest yields is described. This facile strategy was also used to synthesize several 4-arylpyridines, 3-hydroxy-4-arylpyridines, and 3,4-diarylpyridines. Crown Copyright