52161-81-6Relevant academic research and scientific papers
NEW SYNTHETIC ROUTE TO N-ACYL-α-AMINO ACIDS VIA AMIDOCARBONYLATION BY MEANS OF HOMOGENEOUS BINARY CATALYST SYSTEMS
Hirai, Kenji,Fujita, Makoto,Fuchikami, Takamasa
, p. 203 - 214 (2007/10/02)
New catalytic processes which lead to the formation of N-acyl-α-amino acids promoted by homogeneous binary systems are described: (a) the isomerization-amidocarbonylation of allylic alcohols catalyzed by transition metal binary systems, e.g., Co-Rh, Co-Pd, Co-Fe, giving various aliphatic N-acyl-α-amino acids; (b) the isomerization-amidocarbonylation of oxiranes catalyzed by cobalt-Lewis acid systems giving N-acyl-α-amino acids; The process is extremely effective for the synthesis of N-acetylphenylalanine from styrene oxide and (c) the hydroformylation-amidocarbonylation of trifluoropropene catalyzed by cobalt-rhodium binary system giving N-acetyltrifluorovaline in excellent regioselectivity and yield.Possible mechanisms for these new processes are discussed.
