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7-hydroxy-3-(4-hydroxy-phenyl)-4-methyl-chromen-2-one, also known as hesperetin, is a naturally occurring flavonoid found in citrus fruits, particularly in the peels and membranes. This bioactive compound exhibits various pharmacological properties, such as antioxidant, anti-inflammatory, and anti-cancer effects. Hesperetin's chemical structure consists of a chromen-2-one core with a 4-methyl group, a 4-hydroxy-phenyl moiety, and two hydroxyl groups at the 7th and 3rd positions. Its antioxidant activity is attributed to its ability to scavenge free radicals and chelate metal ions, while its anti-inflammatory properties are linked to the inhibition of pro-inflammatory enzymes and cytokines. Additionally, hesperetin has been shown to possess potential anti-cancer effects by modulating various signaling pathways involved in cell proliferation, apoptosis, and angiogenesis. Overall, hesperetin's diverse biological activities make it a promising candidate for the development of novel therapeutic agents targeting various diseases.

5217-89-0

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5217-89-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5217-89-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,1 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5217-89:
(6*5)+(5*2)+(4*1)+(3*7)+(2*8)+(1*9)=90
90 % 10 = 0
So 5217-89-0 is a valid CAS Registry Number.

5217-89-0Downstream Products

5217-89-0Relevant academic research and scientific papers

Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases

Valente, Sergio,Bana, Emilie,Viry, Elodie,Bagrel, Denyse,Kirsch, Gilbert

scheme or table, p. 5827 - 5830 (2010/11/17)

The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents.

Estrogen receptor-β ligands

-

, (2008/06/13)

A method for treating a disease associated with the estrogen receptor-β, comprising the step of administering a therapeutically-effective amount of a compound that satisfies the equation: (KiαA/KiβA)/(KiαE

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