5217-88-9

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 75908-67-7 3-bromo-7-methoxy-4-methylcoumarin 
• 5720-07-0 4-methoxyphenylboronic acid 
• 23226-88-2 7-acetoxy-3-(4-methoxy-phenyl)-4-methyl-coumarin 
• 5219-16-9 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 5217-89-0 7-hydroxy-3-(4-hydroxy-phenyl)-4-methyl-chromen-2-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases

The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents.

A novel one-step synthesis of 3-phenyl-, 4-methyl-3-phenyl- And3-phenyl-4-styrylcoumarins using DCC-DMSO

2-Hydroxybenzaldehydes 1 react with phenylacetic acid and its methoxy derivatives 2 in the presence of DCC in DMSO to afford 3-phenylcoumarins 3. Under identical conditions, 2-hydroxy-acetophenones 4 and 2'-hydroxychalcones 7 give rise to the corresponding 4-methyl-3-phenyl- and 3-phenyl-4-styrylcoumarins 6 and 8, respectively.