52177-63-6

Upstream product

• 75-44-5 phosgene 
• 1073-72-9 4-hydroxythioanisole 

Downstream Products

• 75521-95-8 4-Methylthiophenoxycarbonyl-L-leucin 
• 75521-99-2 O-(4-Methylthiophenoxycarbonyl-L-leucyl-L-lactyl-L-leucyl)-L-milchsaeure-tert-butylester 
• 75521-98-1 Mspc-L-Leu-L-Lac-OtBu 
• 75521-96-9 Mtpc-L-Leu-L-Lac-OtBu 
• 75521-97-0 Mtpc-L-Leu-L-Lac-OH 
• 79112-95-1 [2-(4-Methylsulfanyl-phenoxycarbonylamino)-acetylamino]-acetic acid 
• 79112-94-0 1-(p-methylthio)-phenyloxycarbonyl-3-methyl-imidazolium chloride 

Relevant academic research and scientific papers

Hapten Synthesis and Production of Monoclonal Antibodies to the N-Methylcarbamate Pesticide Methiocarb

With the aim of developing an immunoassay for the detection of the insecticide methiocarb, three compounds with carboxylic spacer arms of different lengths introduced at the carbamate group were synthesized, conjugated to proteins, and used as immunizing haptens in mice. Monoclonal antibodies (MAbs) were subsequently obtained and characterized for their affinity to methiocarb. In the homologous conjugate-coated assay format, MAbs exhibited I5o values in the 1 -10 nM range. Thereafter, a collection of methiocarb haptens with modifications in the aromatic ring structure or in the spacer arm were synthesized to be used as heterologous haptens. These haptens and MAbs were incorporated into several ELISA configurations. Some of the new combinations of immunoreagents and assay format provided a significant improvement in assay sensitivity, reaching I50 values around 0.1 nM. MAbs seem to be very specific for methiocarb, as evidenced by the negligible cross-reactivity shown by methiocarb metabolites. These immunoreagents are very promising analytical tools for the rapid and sensitive determination of methiocarb in food and in the environment.

Process for production of sulfonium compounds and novel methylthiphenol derivatives

Disclosed is process for producing a sulfonium compound of the general formula (III), comprising reacting alkylthiophenol derivative of the general formula (I) and dialkyl sulfate of the general formula (II) in the presence of at least one inorganic compound selected from the group consisting of alkali metal carbonate, alkali metal hydrogencarbonate, alkaline earth metal hydroxide, alkaline earth metal carbonate, and oxides of Group II metals of the Periodic Table. STR1 wherein all the symbols are as defined in the appended claims.

1-Aziridine carboxylic acid derivatives with immunostimulant activity

2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula STR1 wherein X is a carbamoyl or alkoxycarbonyl radical, and R1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R1 is as above, except for ethyl, are also new.