52178-61-7

Upstream product

• 64896-33-9 (Z)-2-acetamido-3-(p-hydroxyphenyl)-2-propenic acid 
• 556-02-5 ?Tyr 
• 52507-17-2 (Z)-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 6482-98-0 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid 
• 214534-53-9 (Z)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discove

Synthesis of new potential HIV-1 integrase inhibitors

A synthesis of some 1,2-(hetero)arylsubstituted ethanone and 1,3-(hetero)arylsubstituted3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achiev

Mechanistic and stereochemical study of phenylpyruvate tautomerase

A variety of substrates and potential enol/enolate mimics for the product/transition state of the enzyme phenylpyruvate tautomerase (E.C. 5.3.2.1) have been prepared and studied. Their stereostructures have been secured by a combination of NMR spectroscopy based on vicinal H-F and H-C coupling constants and X-ray crystallography. On the basis of the inhibition by stereoisomeric substituted cinnamates, it has been concluded that the enzyme produces the thermodynamically less stable (E) enol via a syn tautomerization transition state. Free energy profiles for the reaction suggest that vinyl fluorides act as product analogues. Because amide and dicarboxylate enolate mimics are relatively poor inhibitors of the enzyme, it is believed that an enolate is not involved in the tautomerization process.

A modified synthesis of (±)-β-aryllactic acids

The synthesis of racemic forms of the reportedly active principle of Danshen, namely (±)-β-(3,4-dihydroxyphenyl)lactic acid [(±)3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid] and its seven racemic derivatives is reported.

Conversion of Phenolic α-Amino Acids into α-Keto Acids

A one-pot conversion of tyrosine (1a) and 3,4-dihydroxyphenylalanine (DOPA) (1b) into 3-(4-hydroxyphenyl)pyruvic acid (2a) and 3-(3,4-dihydroxyphenyl)pyruvic acid (2b), respectively, via 2-trifluoromethyl-3-oxazolin-5-ones 5 is described.