52507-17-2

Upstream product

• 1145-56-8 2-(2-chloroacetamido)-3-(4-hydroxyphenyl)propanoic acid 
• 108-24-7 acetic anhydride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 543-24-8 N-acetylglycine 
• 56-40-6 glycine 
• 127-09-3 sodium acetate 
• 69932-90-7 N-benzylsulfanylcarbonyl-glycine 
• 878-00-2 4-formylphenyl acetate 
• 24474-93-9 2-methyl-4H-oxazol-5-one 
• 71428-89-2 N-crotonylglycine 
• 124-40-3 dimethyl amine 

Downstream Products

• 52507-18-3 4-acetoxy-α-acetylamino-cinnamic acid 
• 52507-28-5 α-Acetylamino-p-hydroxy-zimtsaeuremethylester 
• 70529-59-8 N,O-diacetyltyrosine azlactone 
• 1446876-39-6 C₁₉H₂₃BrN₂O₄ 
• 1446876-44-3 C₁₇H₂₀N₂O₃ 
• 1446876-37-4 C₁₉H₂₄N₂O₄ 
• 58848-83-2 3,4-dihydro-6-(4-hydroxybenzyl)-3-sulfanyl-1,2,4-triazin-5(2H)-one 
• 6482-98-0 2-hydroxy-3-(4-hydroxyphenyl)propanoic acid 
• 64896-33-9 (Z)-2-acetamido-3-(p-hydroxyphenyl)-2-propenic acid 
• 64896-34-0 (Z)-α-Acetamido-p-acetyloxycinnamic Acid 
• 200940-00-7 (Z)-4-(4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one 
• 900181-24-0 (Z)-1-ethyl-4-(4-hydroxybenzylidene)-2-methyl-1H-imidazol-5(4H)-one 
• 1006615-07-1 (Z)-5-(4-hydroxybenzylidene)-3-(2-hydroxyethyl)-2-methyl-3,5-dihydro-4H-imidazol-4-one 

Relevant academic research and scientific papers

Evidence of the structure of 4-(4′-acetoxybenzylidene)-2-methyl-5-oxazolone and its phenylpropenoic acid derivatives

4-(4′-Acetoxybenzylidine)-2-methyl-5-oxazolone (Z-isomer) was synthesized, which upon basic hydrolysis yielded the unexpected 2-acetoxy-3-(p-hydroxyphenyl)-propenoic acid and treatment with acetic acid formed 2-acetoxy-3-(p-acetoxyphenyl)-propenoic acid. The structures of the three compounds were assigned by NMR spectroscopy. An X-ray crystallographic study of the starting azlactone confirmed its structure and supported the fact that the Z-configuration was retained during the synthesis of the phenylpropenoic acid derivatives.

Concise Modular Synthesis of Thalassotalic Acids A-C

The novel N-acyldehydrotyrosine analogues known as thalassotalic acids A-C were isolated from a marine bacterium by Deering et al. in 2016. These molecules were shown to have tyrosinase inhibition activity and thus are an attractive set of molecules for further study and optimization. To this end, a concise and modular synthesis has been devised and executed to produce thalassotalic acids A-C and two unnatural analogues. This synthesis has confirmed the identity and inhibitory data of thalassotalic acids A-C, more potent synthetic analogues (IC50 = 65 μM), and provides a route for further structure-activity relationship studies to optimize these molecules.

An Atropos Chiral Biphenyl Bisphosphine Ligand Bearing Only 2,2′-Substituents and Its Application in Rh-Catalyzed Asymmetric Hydrogenation

An atropos chiral biphenyl bisphosphine ligand bearing only 2,2′-substituents was rationally designed and easily synthesized utilizing a bulky chiral t-butylmethylphosphino block. Computational results showed a large difference in the free energies betwee

With antibiotic compound of ability and its preparation method and use thereof

The invention discloses application of a 3-aryl-6-aryl-7H-thiazolo [3,2-b]-1,2,4-triazine-7-ketone derivative with a general formula I shown in the description to an antibacterial drug. In the general formula I, R1 and R2 are methyl, halogen, hydroxyl, methoxyl, acetyl, propionyl, formylphenyl, carbamoyl-methoxy-benzyl, 4-methylanilino formyl-methoxyl or chloroaniline formyl-methoxyl respectively and independently. The 3-aryl-6-aryl-7H-thiazolo [3,2-b]-1,2,4-triazine-7-ketone derivative, namely an antibacterial compound provided by the invention, has obvious inhibiting effects on methicillin-resistant staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and a variety of bacteria, and can be used for the preparation of the antibacterial drug.

New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof

PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.

Confined chromophores in tobacco mosaic virus to mimic green fluorescent protein

Due to the nano-confinement effect, grafting green fluorescent protein-like chromophores on the interior surface of tobacco mosaic virus can greatly enhance its fluorescence emission in various solvents.

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Efficient synthetic approach to fluorescent oxazole-4-carboxylate derivatives

In our attempt to synthesize a halogenated analog of green fluorescent protein (GFP) chromophore, we discovered a simple and efficient synthetic strategy to the derivatives of oxazole-4-carboxylic acid substituted at positions 2 and 5. The method allows f

Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.

Concerning the thermal diastereomerization of the green fluorescent protein chromophore

Two model compounds for the green fluorescent protein chromophore were prepared. One of them incorporates the natural 4-hydroxybenzylidene group of the natural tyrosin derived chromophore, the other one bears a methyl group instead of the hydroxy group. W