52182-34-0

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 84857-15-8 4-(3-Chloro-phenyl)-6-p-tolyl-pyrimidin-2-ylamine 
• 1878-65-5 3-chlorophenylacetic acid 
• 99-94-5 p-Toluic acid 
• 1204687-43-3 C₂₈H₂₃ClN₄ 
• 1374585-14-4 4-(3-chlorophenyl)-6-p-tolyl-2,2'-bipyridine 

Relevant academic research and scientific papers

1, 2, 4-triazoles clubbed pyrimidine compounds with synthesis, antimicrobial, antituberculosis, antimalarial, and anti-protozoal studies

Triazoles are famous as an antifungal agent. Itraconazole and fluconazole are the best examples of antifungal drugs available in the market, which consist of an active triazole moiety. Pyrimidines are also bioactive molecules which shows multiple bioactivity. It’s an effort to synthesize pyrimidine clubbed triazole to enhance bioactivity. To synthesize new active pyrimidine clubbed triazole biomolecule and to evaluate these new products for better drug potential as antimicrobial, antituberculosis, antimalarial, and anti-protozoal, N-[4-(substituted phenyl)-6-(substituted aryl) pyrimidine-2-yl]-2-[(4H-1,2,4-triazol-4-yl)amino]acetamide(3A-J) were synthesized by different method such as cyclization, condensation, purification and crystallization. The newly synthesized compounds were characterized by IR,1H NMR,13C NMR and mass spectral analysis and screened for antibacterial, antifungal, anti-tuberculosis, antimalarial, and antiprotozoal activities. These compounds satisfied the bioactive response and simple way for the synthesis.

Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

Ca(OTf)2 in combination with NBu4.BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials.

Synthesis of 1,3,5-trisubstituted pyrazoline derivatives and their applications

A series of 1,3,5-trisubstituted pyrazolines based homoleptic Ru(iii) complexes of type [Ru(L1-7)3]·(PF6)3 (L1-7 = pyrazoline ligands) have been synthesized and characterized by elemental analysis, el

Synthesis, spectral investigation and biological interphase of drug-based cytotoxic square pyramidal coordination compounds

We have synthesized ciprofloxacin-based metal complexes of bipyridine derivatives [Cu(CFL)(An)Cl].2H2O (where CFL=ciprofloxacin and A=bipyridines e.g. A1=4-(4-fluorophenyl)-6-p-tolyl-2,2′- bipyridine, A6=4-(4-(b

Synthesis and biological activity of 3-aryl-5-(3′ -bromo/chlorophenyl)isoxazoles

3-Aryl-5-(3′-bromo/chlorophenyl)isoxazole derivatives (3a-j, 4a-j) have been prepared by condensing 1-aryl-3-(3′-bromo/ chlorophenyl)-2-propen-1-ones (1a-j, 2a-j) with hydroxylamine hydrochloride. Compounds 1a-j, 2a-j have been synthesized by the reaction

Multiple substituent effects on 13C chemical shifts in phenylstyryl ketones: Applicability of interactive free energy relationship

13C chemical shifts for 23 mono- and di-substituted phenyl styryl ketones have been determined. The shieldings and deshieldings are compared with previous results for other aromatic derivatives. Correlations of the 13C chemical shifts of vinyl carbons with Hammett σ parameters has been determined to provide a consistent picture of electronic effects transmitted through the carbon framework of the compounds studied. Slopes obtained from such Hammett's plots are termed as ρ, and using these 'ρ' values applicability of interactive free energy relationship to chemical shift values has been tested. The cross- interaction constants qx and qy values for C-α are found to be -1.02 and -1.20 and for C-β are -1.46 and -1.19.

Interactive free energy relationships for non-additive multiple substituent effects in base catalysed condensation of benzaldehydes with acetophenones: A kinetic study

The base-catalysed condensation of benzaldehydes with acetophenones is enhanced by electron-withdrawing substituents in both starting compounds.The magnitude of ρ-value obtained for various substituents in the benzaldehyde moiety decreases with the introduction of electron-withdrawing groups in the para position of acetophenone moiety.