5219-16-9

Basic information

• Product Name: 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one
• Synonyms: 2H-1-benzopyran-2-one, 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-; 5219-16-9; 7-Hydroxy-3-(4-methoxyphenyl)-4-methylcoumarin
• CAS NO: 5219-16-9
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.2907
• Mol File: 5219-16-9.mol

Chemical Properties

• Boiling Point: 500.6°C at 760 mmHg
• Flash Point: 188.7°C
• Density: 1.284g/cm³
• Vapor Pressure: 1.21E-10mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one(5219-16-9)
• EPA Substance Registry System: 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one(5219-16-9)

Safety Data

• Hazardous Substances Data: 5219-16-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one is used as a therapeutic agent for its antioxidant, anti-inflammatory, and anti-cancer properties. It can potentially be developed into a pharmaceutical product to treat various diseases and conditions, including cancer and chronic inflammatory disorders.
Used in Nutraceutical Applications:
In the nutraceutical industry, 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one is used as a dietary supplement or functional food ingredient to promote overall health and well-being. Its antioxidant and anti-inflammatory properties can contribute to the prevention of chronic diseases and support a healthy immune system.
Used in Cardiovascular Health Applications:
7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one is used as a cardiovascular health promoter due to its potential to improve heart function and reduce the risk of cardiovascular diseases. Its antioxidant properties can help protect the heart from oxidative stress and inflammation, contributing to better cardiovascular health.
Used in Cosmetic Applications:
In the cosmetic industry, 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one can be used as an active ingredient in skincare products for its antioxidant and anti-inflammatory properties. It may help protect the skin from environmental damage, reduce inflammation, and promote a healthier, more youthful appearance.
Used in Agricultural Applications:
7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one can be used in agriculture as a natural pesticide or growth promoter due to its antioxidant and anti-inflammatory properties. It may help protect plants from oxidative stress and promote healthy growth, reducing the need for synthetic chemicals in agriculture.
Overall, the diverse applications of 7-hydroxy-3-(4-methoxyphenyl)-4-methyl-2H-chromen-2-one highlight its potential as a versatile compound with significant health and wellness benefits. Further research and development are needed to fully explore its potential and optimize its use in various industries.

Upstream product

• 5219-08-9 2-(4-methoxyphenyl)acetoacetic acid ethyl ester 
• 108-46-3 recorcinol 
• 7664-93-9 sulfuric acid 
• 63895-78-3 2-(4-methoxyphenyl)-3-oxobutanenitrile 
• 104-47-2 p-methoxybenzylnitrile 
• 104-01-8 4-Methoxyphenylacetic acid 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 108-24-7 acetic anhydride 
• 23226-88-2 7-acetoxy-3-(4-methoxy-phenyl)-4-methyl-coumarin 
• 81685-26-9 (Z)-3-hydroxy-2-(4-methoxyphenyl)but-2-enenitrile 

Downstream Products

• 75256-73-4 5-Methyl-6-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-2,3-diphenyl-furo[3,2-g]chromen-7-one 
• 75256-72-3 5-Methyl-2,3-diphenyl-6-[4-(2-piperazin-1-yl-ethoxy)-phenyl]-furo[3,2-g]chromen-7-one 
• 75256-71-2 5-Methyl-2,3-diphenyl-6-[4-(3-piperidin-1-yl-propoxy)-phenyl]-furo[3,2-g]chromen-7-one 
• 75256-74-5 5-Methyl-2,3-diphenyl-6-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-furo[3,2-g]chromen-7-one 
• 75256-70-1 2,3-Diphenyl-6--5-methyl-7(H)-oxofuro<3,2-g><1>benzopyran 
• 75256-63-2 2,3-Diphenyl-6-p-methoxyphenyl-5-methyl-7(H)-oxofuro<3,2-g><1>benzopyran 
• 75256-65-4 2,3-Diphenyl-6-(p-hydroxyphenyl)-5-methyl-7(H)-oxofuro<3,2-g><1>benzopyran 
• 75256-61-0 7-O-Desyl-3-p-methoxyphenyl-4-methylcoumarin 
• 5217-88-9 7-methoxy-3-(4-methoxy-phenyl)-4-methyl-coumarin 

Relevant articles and documents

Photocatalytic surface patterning of cellulose using diazonium salts and visible light

Coumarin-functionalized cellulose sheets were chemically modified using a visible light catalyzed "Photo-Meerwein" arylation. Use of a photomask to pattern the surface resulted in directly visible images.

Discovery and structure-activity relationship of coumarin derivatives as TNF-α inhibitors

The discovery and structure-activity relationship of a novel series of coumarin-based TNF-α inhibitors is described. Starting from the initial lead 1a, various derivatives were prepared surrounding the coumarin core structure to optimize the in vitro inhibitory activity of TNF-α production by human peripheral blood mononuclear cells (hPBMC), stimulated by bacterial lipopolysaccharide (LPS). Selected compounds also demonstrated in vivo inhibition of TNF-α production in rats.

Synthesis of 2,3-Diphenyl-6-(p-substituted phenyl)-5H/methyl-7(H)-oxofurobenzopyrans as Possible Antifertility Agents

Synthesis and antiimplantation activity of some 2,3-diphenyl-6--5H/methyl-7(H)-oxofurobenzopyrans (Va-d and VIa-e) are reported.Of these 2,3-diphenyl-6--5-methyl-7(H)-oxofurobenzopyran (VIa) shows significant activity.