5219-44-3Relevant academic research and scientific papers
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors
Wu, Yiran,Chen, Zheng,Liu, Ying,Yu, Lanlan,Zhou, Lu,Yang, Suijia,Lai, Luhua
, p. 3361 - 3366 (2011/07/29)
A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A2 (hnps-PLA2) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA2 inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 μM. The structure-inhibition-activity relationships of the compounds were studied using molecular docking.
Synthesis and photophysical properties of 2-Styrylquinazolin-4-ones
Trashakhova,Nosova,Valova,Slepukhin,Lipunova,Charushin
body text, p. 753 - 761 (2011/08/22)
Trans-2-Styryl-substituted 3H-, 3-phenyl-, and 3-naphthylquinazolin-4-ones and their 6,7-difl uoro derivatives were synthesized by condensation of appropriate 2-methylquinazolin-4-ones with aromatic aldehydes or by the transformation of the heterocycle of 2-methyl-3,1-benzoxazin-4-one under the action of benzylidenephenylamines. Pleiades Publishing, Ltd., 2011.
Synthesis and antimicrobial activity of 1-(p-substituted)phenyl-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-ones
Vittoria Diurno,Cristinziano,Mazzoni,Piscopo,Bolognese
, p. 143 - 148 (2007/10/02)
A series of 1-(p-substituted)phenyl)-3-(p-alkoxy)phenyl-4-phenyl-azetidin-2-ones 1a-20a, was synthesized and characterized. Their antimicrobial activity, against Gram+ and Gram - bacteria and Fungi, was tested. The compounds 8a, 13a, 14a, 18a and 6a, 9a,
