52190-20-2Relevant academic research and scientific papers
In vitro evaluation of antifungal properties of 8.O.4'-Neolignans
Zacchino, Susana,Rodriguez, Gladis,Pezzenati, German,Orellana, Gabriela,Enriz, Ricardo,Sierra, Manuel Gonzalez
, p. 659 - 662 (1997)
Eighteen racemic 8.O.4'-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and threo alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (±)-erythro-3,4- (methylenedioxy)-7-hydroxy-1'-allyl-3',5'-dimethoxy-8.O.4'-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.
