52191-26-1

Basic information

• Product Name: 3-(CHLOROACETAMIDOETHYL)INDOLE
• Synonyms: 3-(CHLOROACETAMIDOETHYL)INDOLE;2-CHLORO-N-(2-INDOL-3-YLETHYL)ETHANAMIDE;2-CHLORO-N-[2-(1H-INDOL-3-YL)ETHYL]ACETAMIDE;2-Chloro-N-[2-(1H-indol-3-yl)ethyl]ethanamide, 3-{2-[(Chloroacetyl)amino]ethyl}-1H-indole;2-chloro-N-[2-(1H-indol-3-yl)ethyl]ethanamide;Tryptamine, N-chloroacetyl-;2-Chloro-N-[2-(1H-indol-3-yl)ethyl]acetamide98%
• CAS NO: 52191-26-1
• Molecular Formula: C₁₂H₁₃ClN₂O
• Molecular Weight: 236.7
• Mol File: 52191-26-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 93 °C
• Boiling Point: 511.8 °C at 760 mmHg
• Flash Point: 263.3 °C
• Appearance: /
• Density: 1.279 g/cm³
• Vapor Pressure: 1.37E-10mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.25±0.46(Predicted)
• CAS DataBase Reference: 3-(CHLOROACETAMIDOETHYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(CHLOROACETAMIDOETHYL)INDOLE(52191-26-1)
• EPA Substance Registry System: 3-(CHLOROACETAMIDOETHYL)INDOLE(52191-26-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 52191-26-1(Hazardous Substances Data)

Usage

General Description

3-(Chloroacetamidoethyl)indole is a chemical compound that consists of a chloroacetamido group attached to an indole ring. It is commonly used in organic synthesis and in the pharmaceutical industry for the development of various drugs and biologically active compounds. 3-(CHLOROACETAMIDOETHYL)INDOLE has several potential applications, including as a building block in the synthesis of complex molecular structures and as a precursor in the production of pharmaceuticals. Additionally, research has shown that 3-(Chloroacetamidoethyl)indole may have potential medicinal properties, such as antifungal and antibacterial activity, making it a valuable compound for further study and development in the field of medicine and drug discovery.

InChI:InChI=1/C12H13ClN2O/c13-7-12(16)14-6-5-9-8-15-11-4-2-1-3-10(9)11/h1-4,8,15H,5-7H2,(H,14,16)

Upstream product

• 61-54-1 tryptamine 
• 79-04-9 chloroacetyl chloride 
• 79-11-8 chloroacetic acid 
• 27243-15-8 N-succinimidyl 2-chloroacetate 

Downstream Products

• 1016-47-3 N-Acetyltryptamine 
• 14482-90-7 6,7,9,10-tetrahydroazepino<4,5-b>indol-8(5H)-one 
• 57964-75-7 1,3,4,5,6,7-hexahydro-6-oxoazocino<4,5,6-cd>indole 
• 503544-97-6 N-[2-(3-indolyl)ethyl]-2-(4-methylphenylsulfonyl)acetamide 
• 135710-19-9 2-(3,4-Dichloro-phenyl)-1-(1-pyrrolidin-1-ylmethyl-1,3,4,9-tetrahydro-β-carbolin-2-yl)-ethanone 
• 473893-99-1 1-{2-(1H-benzo[b]azol-3-yl)ethyl}-3-(4-methylphenylsulfonyl)-2,6-azinanedione 

Relevant articles and documents

AN ACTIVITY-GUIDE MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS

Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

Insecticidal activity of indole derivatives against Plutella xylostella and selectivity to four non-target organisms

The diamondback moth Plutella xylostella (Linnaeus, 1758) (Lepidoptera: Plutellidae) is a destructive pest of brassica crops of economic importance that have resistance to a range of insecticides. Indole derivates can exert diverse biological activities, and different effects may be obtained from small differences in their molecular structures. Indole is the parent substance of a large number of synthetic and natural compounds, such as plant and animal hormones. In the present study, we evaluate the insecticidal activity of 20 new synthesized indole derivatives against P. xylostella, and the selectivity of these derivatives against non-target hymenopteran beneficial arthropods: the pollinator Apis mellifera (Linnaeus, 1758) (Hymenoptera: Apidae), and the predators Polybia scutellaris (White, 1841), Polybia sericea (Olivier, 1791) and Polybia rejecta (Fabricius, 1798) (Hymenoptera: Vespidae). Bioassays were performed in the laboratory to determine the lethal and sublethal effects of the compounds on P. xylostella and to examine their selectivity to non-target organisms by topical application and foliar contact. The treatments consisted of two synthesized derivatives (most and least toxic), the positive control (deltamethrin) and the negative control (solvent). The synthesized compound 4e [1-(1H-indol-3-yl)hexan-1-one] showed high toxicity (via topical application and ingestion) and decreased the leaf consumption by P. xylostella, displaying a higher efficiency than the pyrethroid deltamethrin, widely used to control this pest. In addition, the synthesized indole derivatives were selective to the pollinator A. mellifera and the predators P. scutellaris, P. sericea and P. rejecta, none of which were affected by deltamethrin. Our results highlight the promising potential of the synthesized indole derivatives for the generation of new chemical compounds for P. xylostella management.

8-aminoquinoline-melatonin complex and pharmaceutical composition thereof

The invention relates to synthesized 8-aminoquinoline-melatonin complex, in particular to an 8-aminoquinoline-melatonin complex and a pharmaceutical composition thereof. The 8-aminoquinoline-melatonin complex is of a structure as shown in the structural formula (I); on one hand, the compounds can selectively chelate copper ions; on the other hand, the compounds play a role in well protecting nerves and nerve cells to improve AD (Alzheimer's disease) symptoms. The invention further relates to a pharmaceutical composition or nerve cell protective agent comprising the complex or pharmaceutically acceptable salt thereof. The invention further relates to pharmaceutical application of the complex.