521969-24-4

Basic information

• Product Name: S-methyl-S-p-tolyl-N-(trifluoroacetyl)sulfilimine
• CAS NO: 521969-24-4
• Molecular Weight: 249.257
• Mol File: 521969-24-4.mol

Chemical Properties

• CAS DataBase Reference: S-methyl-S-p-tolyl-N-(trifluoroacetyl)sulfilimine(CAS DataBase Reference)
• NIST Chemistry Reference: S-methyl-S-p-tolyl-N-(trifluoroacetyl)sulfilimine(521969-24-4)
• EPA Substance Registry System: S-methyl-S-p-tolyl-N-(trifluoroacetyl)sulfilimine(521969-24-4)

Safety Data

• Hazardous Substances Data: 521969-24-4(Hazardous Substances Data)

Upstream product

• 354-38-1 2,2,2-trifluoroacetamide 
• 623-13-2 4-methylphenyl methylsulfide 

Downstream Products

• 58044-92-1 S-methyl-S-(4-tolyl)sulfilimine 

Relevant articles and documents

Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

A novel method for preparing a diverse range of o-sulfanylanilines is described. Direct thioamination of arynes with sulfilimines gives o-sulfanylanilines, involving C-N and C-S bond formations and migratory N-arylation.

A practical approach to N-(trifluoroacetyl)sulfilimines

A new, simple method for the synthesis of N-(trifluoroacetyl)-protected sulfilimines from sulfides by a transition-metal-free, one-pot protocol is presented. The salient features of this process include the use of low-cost 1,3-dibromo-5,5-dimethylhydantoin, mild reaction conditions, and a broad substrate scope. The safety and robustness of the method has also been demonstrated by operations on a kilogram scale. In addition, a chiral resolution of a corresponding sulfoximine was achieved on a large scale. Georg Thieme Verlag Stuttgart. New York.

PROCESS FOR PREPARING PAN-CDK INHIBITORS OF THE FORMULA (I), AND INTERMEDIATES IN THE PREPARATION

The invention relates to a novel process for the preparation of pan-CDK inhibitors of the formula (I), and intermediates of the preparation.