52206-06-1

Usage

Structure

A sulfonamide derivative of indole, commonly found in natural products and pharmaceuticals

Biological activities

Antimicrobial, antiviral, anti-inflammatory, and antitumor properties

Potential applications

Medicine and biotechnology

Use as building block

For the synthesis of new pharmaceutical compounds for various therapeutic purposes

Fluorescence-based probe

For detecting and analyzing specific biological targets in cellular and molecular imaging studies.

InChI:InChI=1/C8H10N2O2S/c9-13(11,12)7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2,(H2,9,11,12)

Upstream product

• 203861-18-1 1-(2,2,2-trifluoroacetyl)indoline-5-sulfonamide 
• 52206-05-0 1-acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride 
• 3264-38-8 1-acetyl-2,3-dihydro-indole-5-sulfonic acid amide 
• 210691-38-6 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride 

Downstream Products

• 1307188-56-2 1-(cyclohexanecarbonyl)indoline-5-sulfonamide 
• 3074-27-9 1H-indole-5-sulfonamide 

Relevant academic research and scientific papers

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

The present invention relates to a compound having a cardiotonic activating function and a pharmaceutical composition containing the same. The composition comprising the compound according to the present invention is effective in preventing or treating heart failure. In addition, the compound is represented by chemical formula 2 or is pharmaceutically acceptable salt thereof.COPYRIGHT KIPO 2016

Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure

Disclosed are a compound having cardiotonic activity and a pharmaceutical composition containing the same, and the composition containing the compound, according to the present invention, is useful for preventing and treating heart failure.COPYRIGHT KIPO 2016

SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS

Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM

The present invention relates to pyrimidine sulfonamide analogs, methods of making pyrimidine sulfonamide analogs, compositions comprising a pyrimidine sulfonamide analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a pyrimidine sulfonamide analog.