52206-36-7Relevant articles and documents
Activation and inhibition of kidney CLC-K chloride channels by fenamates
Liantonio, Antonella,Picollo, Alessandra,Babini, Elena,Carbonara, Giuseppe,Fracchiolla, Giuseppe,Loiodice, Fulvio,Tortorella, Vincenzo,Pusch, Michael,Camerino, Diana Conte
, p. 165 - 173 (2007/10/03)
CLC-K Cl- channels are selectively expressed in kidney and ear, where they are pivotal for salt homeostasis, and loss-offunction mutations of CLC-Kb produce Bartter's syndrome type III. The only ligand known for CLC-K channels is a derivative o
Nicotinamide Ethers: Novel Inhibitors of Calcium-Independent Phosphodiesterase and Rolipram Binding
Vinick, Fredric J.,Saccomano, Nicholas A.,Koe, B. Kenneth,Nielsen, Jann A.,Williams, Ian H.,et al.
, p. 86 - 89 (2007/10/02)
The synthesis and biological properties of a series of nicotinamide ethers are described.These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of rolipram to rat brain membranes and reverse rese