52222-45-4Relevant academic research and scientific papers
Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors
Gillerman, Irina,Fischer, Bilha
, p. 107 - 121 (2011/03/19)
Inhibitors of adenosine deaminase (ADA, EC 3.5.4.4) are potential therapeutic agents for the treatment of various health disorders. Several highly potent inhibitors were previously identified, yet they exhibit unacceptable toxicities. We performed a SAR s
CHEMICAL COMPOUNDS - 795
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Page/Page column 25, (2009/04/25)
The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which have bacterial Murl inhibitory activity and are accordingly useful for their treatment and prophylaxis of bacterial infection, e.g., E.faec
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
Breault, Gloria A.,Comita-Prevoir, Janelle,Eyermann, Charles J.,Geng, Bolin,Petrichko, Randy,Doig, Peter,Gorseth, Elise,Noonan, Brian
scheme or table, p. 6100 - 6103 (2009/07/18)
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
