52236-30-3

Usage

Uses

Used in Agricultural Industry:
METRIBUZIN-DESAMINO-DIKETO is used as a fungicide for protecting crops from various fungal infections. Its application helps in reducing the spread of diseases and ensuring a healthy growth of plants, leading to increased crop yields.
METRIBUZIN-DESAMINO-DIKETO is also used as a herbicide to control the growth of unwanted plants and weeds in agricultural fields. By inhibiting the photosynthesis process in these plants, it helps in maintaining the dominance of the desired crop species and reduces competition for resources such as nutrients, water, and sunlight.

InChI:InChI=1/C7H11N3O2/c1-7(2,3)4-5(11)8-6(12)10-9-4/h1-3H3,(H2,8,10,11,12)

Upstream product

• 66392-60-7 2-thio-5-(tert-butyl)-6-azauracil 
• 21087-64-9 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one 
• 35045-02-4 6-t-butyl-3-methylthio-1,2,4-triazine-5(4H)-one 
• 56507-37-0 4-amino-6-tert-butyl-1,2,4-triazine-3,5(2H,4H)-dione 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 815-17-8 trimethylpyruvic acid 
• 91912-92-4 3,3-dimethyl-2-thiosemicarbazono-butyric acid 

Downstream Products

• 205439-06-1 5-tert-butyl-1-(2-deoxy-3,5-di-O-toluoyl-β-D-erythro-pentofuranosyl)-6-azauracil 

Relevant academic research and scientific papers

Biomimetic oxidation of metribuzin with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides

The biomimetic oxidation of metribuzin, a pre- and post-emergence herbicide with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides [TAPFe(III)Cl], has been studied yielding 6-t-butyl-3-methylthio-1,2,4-triazine-5(4H)-one, 4-amino-6-t-butyl-3,5(2H,4H)-dione and 6-t-butyl-1,2,4-triazin-3,5(2H,4H)-dione under various reaction conditions.

Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase

The synthesis and X-ray crystal structures of a series of 5- substituted-6-aza-2'-deoxyuridines is reported. These nucleoside analogues inhibit the phosphorylation of thymidine by HSV-1 TK but have no effect on the corresponding human enzyme. Detailed examination of one analogue proves it to be a competitive inhibitor of thymidine with a Ki of 0.34 μM and is a very poor substrate. The analogues are not substrates for the enzyme and also do not inhibit the degradation of thymidine by thymidine phosphorylase. Molecular modelling showed that the inhibitors fit well in the active site of HSV-1 TK, provided the conformation of the sugar moiety is the same for thymidine in the complex.

SPECIFIC DEAMINATION OF 4-AMINO-1,2,4-TRIAZIN-5(4H)-ONES BY CATALYTIC OXIDATION WITH t-BUTYLHYDROPEROXIDE. A CHEMICAL MODEL FOR METABOLISM OF 1,2,4-TRIAZINE HERBICIDES

The oxidation of 4-amino-1,2,4-triazine herbicides (1) with t-butylhydroperoxide catalyzed by Co(Salen) resulted in the specific deamination of the 4-amino group, providing a chemical model for the metabolism of the herbicides.