52240-28-5Relevant articles and documents
Peculiarities of the behavior of succinyl dichloride in Friedel-Crafts reaction with thiophenes
Smirnov,Afanas'Ev,Belen'kii
scheme or table, p. 1199 - 1207 (2011/10/13)
The reactions of thiophene, 2-methyl-, and 2-bromothiophene with succinyl dichloride in the presence of AlCl3, TiCl4, and SnCl 4 have been studied. The effect of the acylation conditions, the relative amounts and nature of the Lewis acid on the ratio and yields of the 1,4-di(2-thienyl)-1,4-diones and 4-oxo-4-(2-thienyl)butyric acids formed have been demonstrated. Under the reaction conditions, the formation of 4,4-di(2-thienyl)but-3-enoic acids (the main products in many cases) and also 4,4-di(2-thienyl)-butyrolactones was demonstrated.
Troublesome alkoxythiophenes. A highly efficient synthesis via cyclization of γ-keto esters
Sonpatki,Herbert,Sandvoss,Seed
, p. 7283 - 7286 (2007/10/03)
A variety of alkoxythiophenes have been synthesized that represent ideal subunits for the synthesis of a new class of thermotropic liquid crystals via palladium-catalyzed cross-coupling reactions and organometallic derivatization. The methodology used represents the first highly efficient synthesis of alkoxythiophenes unlike previous pathways that have presented serious synthetic difficulties when the alkoxy chain consisted of more than four carbon atoms. The scope of the new procedure (relative to liquid crystalline intermediates) is presented and is compared and contrasted with the current literature.
