54145-18-5

Upstream product

• 613-70-7 2-methoxyphenyl acetate 
• 108-24-7 acetic anhydride 
• 90-05-1 2-methoxy-phenol 
• 108-95-2 phenol 
• 7368-78-7 4-bromoguaiacol 
• 75-36-5 acetyl chloride 

Downstream Products

• 7368-78-7 4-bromoguaiacol 
• 1392399-31-3 3-(4-acetoxy-3-methoxyphenyl)-6,7-dimethoxy-4-(2-hydroxyethyl)isoquinoline 
• 1392399-32-4 4-(4-acetoxy-3-methoxyphenyl)-6,7-dimethoxy-3-(2-hydroxyethyl)isoquinoline 
• 1392399-35-7 3-(4-acetoxy-3-methoxyphenyl)-6,7-dimethoxy-4-(2-oxoethyl)isoquinoline 
• 1392399-37-9 3-(4-acetoxy-3-methoxyphenyl)-6,7-dimethoxy-2-methyl-4-(2-oxoethyl)isoquinolinium iodide 
• 52259-64-0 fagaronine 
• 1392399-29-9 4-(4-acetoxy-3-methoxyphenyl)-3-butyn-1-ol 
• 1430838-73-5 C₁₄H₁₈O₃Si 
• 881-68-5 vanillin acetate 
• 93-28-7 eugenol acetate 

Relevant academic research and scientific papers

Polymerizable liquid crystal compound

PROBLEM TO BE SOLVED: To provide a polymerizable compound giving high refractive index anisotropy, a wide liquid crystal phase temperature range and high storage stability to a liquid crystal composition and producing a polymer film having high pattern resolution, high heat resistance, and little haze and white irregularity when polymerizing the liquid crystal composition. SOLUTION: The polymerizable compound is represented by general formula (I). The polymerizable liquid crystal composition contains the polymerizable compound as a structural member. COPYRIGHT: (C)2013,JPOandINPIT

Efficient microwave-assisted one-pot three-component synthesis of 2,3-disubstituted benzofurans under Sonogashira conditions

An efficient one-pot method for the synthesis of 2,3-disubstituted benzo[b]furans from commercially available 2-iodophenols, terminal acetylenes and aryl iodides has been developed utilizing Sonogashira reaction conditions. After an initial Sonogashira coupling of the 2-iodophenol with the terminal alkyne, cyclization involving the aryl iodide provides the 2,3-disubstituted benzo[b]furan in good to excellent yields. The use of microwave irradiation shortens the reaction times and minimizes the side products. This methodology is especially useful for the construction of libraries of highly substituted benzo[b]furans and their analogues.

Bromination of phenols in bromoperoxidase-catalyzed oxidations

Phenol and ortho-substituted derivatives furnish products of selective para-bromination, if treated with sodium bromide, hydrogen peroxide, and the vanadate(V)-dependent bromoperoxidase I from the brown alga Ascophyllum nodosum. Relative rates of bromination in morpholine-4-ethane sulfonic acid (MES)-buffered aqueous tert-butanol (pH 6.2) increase by a factor 32, as the ortho-substituent in a phenol changes from F via Cl, OCH3, C(CH 3)3, and H to CH3. The polar effect in phenol bromination by the enzymatic method, according to a Hammett-correlation (ρ=-3), compares to reactivity of molecular bromine under identical conditions (ρ=-2). Hypobromous acid is not able to electrophilically substitute bromine for hydrogen at pH 6.2 in aqueous tert-butanol. The tribromide anion behaves in MES-buffered aqueous tert-butanol as electrophile (ρ～-3), showing a similar polar effect in phenol bromination as molecular bromine.

Short synthesis and antimalarial activity of fagaronine

Herein, we report a new synthesis of fagaronine 1, inspired by the synthesis reported by Luo for nornitidine. The in vitro biological activity of fagaronine against malaria on several chloroquine-sensitive and resistant Plasmodium falciparum strains was c

Kumada-Corriu cross coupling route to the anti-cancer agent combretastatin A-4

A short and efficient synthesis of the anticancer agent combretastatin A-4 was accomplished from inexpensive starting materials using the iron-catalyzed cross-coupling of a Grignard reagent and a bromostilbene as the key step. Copyright Taylor & Francis Group, LLC.

Block modification of rod-shaped π conjugated carbon frameworks with donor and acceptor groups toward highly fluorescent molecules: Synthesis and emission characteristics

To create organic molecules that are highly fluorescent at a longer wavelength region, we investigated the synthesis (using Pd-catalyzed cross-coupling) and photophysical properties (Φ f, λ em, τ , λ abs, and ε ) of the following π conjugated molecular rods consisting of p-phenyleneethynylene units modified by donor (OMe) and/or acceptor (CN) groups: (1) side-donor modification systems (SD systems), (2) side-acceptor modification systems (SA systems), and (3) systems consisting of a donor block and an acceptor block (BL systems). As a consequence, very high Φ f values (>0.95) were obtained for BL systems. Bathochromic shifts of λ em for the same π conjugation length were largest for BL systems. Thus we succeeded in creating highly efficient light emitters at a longer wavelength region by block modification (e.g., Φ f = 0.97, λ em = 464 nm for BL-9). Considerably intense solid emission (Φ f ～ 0.5) at a longer wavelength region (500- 560 nm) was also found for BL systems. It has been found that BL-6 and BL-8 exhibit interesting two photon absorption characteristics. This journal is The Royal Society of Chemistry.