52260-22-7

Basic information

• Product Name: Benzenemethanimine, N-chloro-a-methyl-
• Synonyms: Benzenemethanimine, N-chloro-a-methyl-
• CAS NO: 52260-22-7
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.611
• Mol File: 52260-22-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanimine, N-chloro-a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanimine, N-chloro-a-methyl-(52260-22-7)
• EPA Substance Registry System: Benzenemethanimine, N-chloro-a-methyl-(52260-22-7)

Safety Data

• Hazardous Substances Data: 52260-22-7(Hazardous Substances Data)

Upstream product

• 618-36-0 rac-methylbenzylamine 
• 34863-18-8 N,N-dichloro-1-phenylethanamine 
• 98-86-2 acetophenone 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 618-36-0 rac-methylbenzylamine 
• 98-86-2 acetophenone 
• 1314243-17-8 methyl 1-methyl-3-phenylisoquinoline-4-carboxylate 
• 1198575-52-8 1-methyl-3-ethyl-4-phenylisoquinoline 
• 1198575-51-7 1,4-dimethyl-3-phenylisoquinoline 
• 1314243-16-7 3,4- bis(4-bromophenyl)-1-methylisoquinoline 
• 1314243-15-6 3,4-bis(4-chlorophenyl)-1-methylisoquinoline 
• 1401548-50-2 3,4-bis(4-fluorophenyl)-1-methylisoquinoline 
• 1314243-14-5 3,4-bis(4-methoxyphenyl)-1-methylisoquinoline 
• 93472-50-5 1-methyl-3,4-diphenylisoquinoline 

Relevant articles and documents

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.

A Mechanochemical-Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles

A mild, efficient, metal- and solvent-free oxidation of primary amines to aldehydes, ketones, and nitriles under ball-milling conditions is presented. This method has proved to be compatible with various functional groups and only requires easily accessible starting materials. Simple purification of the reaction mixtures by short-column chromatography afforded pure aldehydes, ketones, and nitriles as products.

Preparation of N-chlor-diorganoketimines

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