52260-22-7

Upstream product

• 98-86-2 acetophenone 
• 34863-18-8 N,N-dichloro-1-phenylethanamine 
• 618-36-0 rac-methylbenzylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 618-36-0 rac-methylbenzylamine 
• 1314243-17-8 methyl 1-methyl-3-phenylisoquinoline-4-carboxylate 
• 1198575-52-8 1-methyl-3-ethyl-4-phenylisoquinoline 
• 1198575-51-7 1,4-dimethyl-3-phenylisoquinoline 
• 1314243-16-7 3,4- bis(4-bromophenyl)-1-methylisoquinoline 
• 1314243-15-6 3,4-bis(4-chlorophenyl)-1-methylisoquinoline 
• 1401548-50-2 3,4-bis(4-fluorophenyl)-1-methylisoquinoline 
• 1314243-14-5 3,4-bis(4-methoxyphenyl)-1-methylisoquinoline 
• 93472-50-5 1-methyl-3,4-diphenylisoquinoline 
• 98-86-2 acetophenone 

Relevant academic research and scientific papers

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.

Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.

A Mechanochemical-Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles

A mild, efficient, metal- and solvent-free oxidation of primary amines to aldehydes, ketones, and nitriles under ball-milling conditions is presented. This method has proved to be compatible with various functional groups and only requires easily accessible starting materials. Simple purification of the reaction mixtures by short-column chromatography afforded pure aldehydes, ketones, and nitriles as products.

Efficient racemization of 1-phenylethylamine and its derivatives

We report on simple and efficient procedure for the racemization of 1-phenylethylamine and its derivatives. In the presence of trichloroisocyanuric acid, N-chloroimine derivative is formed as the intermediates, with subsequent hydrogenation catalyzed by Pd-C leading to the racemic product.