522602-16-0

Usage

Uses

Used in Pharmaceutical Industry:
[3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER is used as a building block for the synthesis of various drugs and pharmaceuticals, due to its ability to interact with certain receptors and enzymes in the brain.
Used in Neurological Disorders Treatment:
In the field of medicine, [3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER is used as a potential treatment for various neurological disorders and conditions, given its capacity to engage with specific brain receptors and enzymes.
Used in Organic Synthesis:
[3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER is also used as a component in organic synthesis, contributing to the development of new chemical compounds and materials.
Used in Chemical Research:
Furthermore, [3-(2-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER is utilized in chemical research, where it aids in the exploration of new chemical reactions and the discovery of novel properties and applications.

Upstream product

• 180002-11-3 [3-(2-Azido-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 52022-77-2 2-(3-nitrophenyl)ethanol 
• 52273-77-5 2-(3-aminophenyl)ethan-1-ol 
• 180002-10-2 tert-butyl N-[3-(2-hydroxyethyl)phenyl]carbamate 
• 1026069-85-1 [3-(2-Bromo-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 76935-75-6 2-(3-aminophenyl)ethylamine 

Downstream Products

• 180002-12-4 [3-(2-Benzyloxycarbonylamino-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 210765-57-4 [2-(3-Amino-phenyl)-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

A method for the selective protection of aromatic amines in the presence of aliphatic amines

A simple and efficient procedure has been developed for the regioselective protection of aromatic amines in the presence of aliphatic amines. The method is general for the preparation of mono-N-Boc, -N-Cbz, -N-Fmoc or -N-Alloc aromatic amines in high yield without affecting the aliphatic amines. This approach is applicable to substituted (aminoalkyl)aniline compounds with different functionalities and was employed to supply gram quantities of the protected aniline product. Georg Thieme Verlag Stuttgart · New York.

N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: Structure-activity studies and demonstration of in vivo activity

Selective inhibition of the neuronal isoform of nitric oxide synthase (NOS) compared to the endothelial and inducible isoforms may be required for treatment of neurological disorders caused by excessive production of nitric oxide. Recently, we described N-(3-(aminomethyl)benzyl)acetamidine (13) as a slow, tight-binding inhibitor, highly selective for human inducible nitric oxide synthase (iNOS). Removal of a single methylene bridge between the amidine nitrogen and phenyl ring to give N-(3- (aminomethyl)phenyl)acetamidine (14) dramatically altered the selectivity to give a neuronal selective nitric oxide synthase (nNOS) inhibitor. Part of this large shift in selectivity was due to 14 being a rapidly reversible inhibitor of iNOS in contrast to the essentially irreversible inhibition of iNOS observed with 13. Structure-activity studies revealed that a basic amine functionality tethered to an aromatic ring and a sterically compact amidine are key pharmacophores for this class of NOS inhibitors. Maximal nNOS inhibition potency was achieved with N-(3-(aminomethyl)phenyl)-2- furanylamidine (77) (K(i-nNOS) = 0.006 μM; K(i-eNOS) = 0.35 μM; K(i-iNOS) = 0.16 μM). Finally, α-fluoro-N-(3-(aminomethyl)phenyl)acetamidine (74) (K(i- nNOS) = 0.011 μM; K(i-eNOS) = 1.1 μM; K(i-iNOS) = 0.48 μM) had excellent brain penetration and inhibited nNOS in a rat brain slice assay as well as in the rat brain (cerebellum) in vivo. Thus, N-phenylamidines should be useful in validating the role of nNOS in neurological disorders.